Clinical Features and Testicular Morphology in Patients with Kallmann Syndrome
Clinical Features and Testicular Morphology in Patients with Kallmann Syndrome
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DOI：
10.1016/j.urology.2011.10.032
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发表时间：
2012-03-01
期刊：
影响因子：
2.1
通讯作者：
Hayashi, Yutaro
中科院分区：
文献类型：
--
作者：
Nishio, Hidenori;Mizuno, Kentaro;Hayashi, Yutaro
卡尔曼综合征（Kallmann syndrome， KS）是一种以特发性促性腺功能减退症（IHH）和嗅觉缺失同时发生为特征的遗传性疾病。在这里，我们提出了3例KS，并进行了详细的描述。病例1通过睾丸活检检查睾丸形态，免疫组化使用抗Ad4BP/SF1抗体检测间质细胞。与我们的预测相反，本研究揭示了睾丸中存在间质细胞。KS患者的睾丸形态比预期的更加多样化，需要进一步的研究来阐明激素对正常睾丸发育的影响。中华泌尿外科杂志（英文版），2012。(C) 2012爱思唯尔公司
Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development. UROLOGY 79: 684-686, 2012. (C) 2012 Elsevier Inc.