SURFACE CHARACTERISTICS AND THE INTERACTION OF COLLOIDAL PARTICLES WITH MOUSE PERITONEAL-MACROPHAGES
SURFACE CHARACTERISTICS AND THE INTERACTION OF COLLOIDAL PARTICLES WITH MOUSE PERITONEAL-MACROPHAGES
复制标题
DOI：
10.1016/0142-9612(87)90099-8
复制
发表时间：
1987-03-01
期刊：
影响因子：
14
通讯作者：
DAVIS, SS
中科院分区：
文献类型：
--
作者：
ILLUM, L;JACOBSEN, LO;DAVIS, SS
使用一系列泊洛沙姆和泊洛沙胺作为包衣剂，研究了空间稳定聚苯乙烯颗粒与小鼠腹腔巨噬细胞相互作用的表面特性的影响。包覆颗粒的特征在于包覆层的厚度，表面电荷和临界絮凝温度。发现相对吞噬摄取随着吸附层厚度的增加而减少，即包衣剂的亲水性聚合物链越长，空间稳定效应越大。
The effect of surface characteristics on the interaction of sterically stabilized polystyrene particles with mouse peritoneal macrophages was studied using a range of poloxamers and poloxamine as coating agents. The coated particles were characterized in terms of thickness of coating layer, surface charge and critical flocculation temperature. The relative phagocytic uptake was found to decrease with increasing adsorbed layer thickness i.e. longer hydrophilic polymer chains of the coating agent and consequently a greater steric stabilization effect.