Superinduction of cytokine gene transcription by ciprofloxacin.
Superinduction of cytokine gene transcription by ciprofloxacin.
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环丙沙星对细胞因子基因转录的超诱导。
DOI：
10.4049/jimmunol.153.1.343
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发表时间：
1994
影响因子：
4.4
通讯作者：
A. Forsgren
中科院分区：
文献类型：
--
作者：
K. Riesbeck;M. Sigvardsson;T. Leanderson;A. Forsgren
除了它们的抗菌特性之外，某些抗生素也是生物反应调节剂。例如，氟化的4-喹诺酮，环丙沙星，在体外刺激的PBL中上调IL-2和IFN-γ的产生。在本研究中，环丙沙星显示出增加IL-1 α、IL-2及其受体、IFN-γ、IL-3、IL-4、粒细胞-巨噬细胞/CSF、TNF-α和巨噬细胞毒素的mRNA水平。作为调查与不同的T细胞有丝分裂原和同种异体抗原，上调IL-2的生产环丙沙星被发现是独立的刺激模式。转录活性分析表明，环丙沙星增强IL-2基因的诱导。环丙沙星还可使活化T细胞核因子（NF-AT-1）和AP-1浓度升高。因此，环丙沙星干扰了几种细胞因子共同的调节途径。
In addition to their antibacterial properties, certain antibiotics are also biologic response modifiers. The fluorinated 4-quinolone, ciprofloxacin, for example, up-regulates IL-2 and IFN-gamma production in PBLs stimulated in vitro. In the present study, ciprofloxacin was shown to increase the levels of mRNA for IL-1 alpha, IL-2 and its receptor, IFN-gamma, IL-3, IL-4, granulocyte-macrophage/CSF, TNF-alpha, and lymphotoxin. As investigated with different T cell mitogens and alloantigens, the up-regulation of IL-2 production by ciprofloxacin was found to be independent of the mode of stimulation. Analysis of transcription activity showed that ciprofloxacin enhances IL-2 gene induction. The concentrations of nuclear factor of activated T cells (NF-AT-1) and AP-1 were also found to be increased by ciprofloxacin. Thus, ciprofloxacin interferes with a regulative pathway common to several cytokines.