Identification of a Novel Neuropathogenic Theiler's Murine Encephalomyelitis Virus
Identification of a Novel Neuropathogenic Theiler's Murine Encephalomyelitis Virus
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DOI：
10.1128/jvi.00274-11
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发表时间：
2011-07-01
影响因子：
5.4
通讯作者：
Albert, Matthew L.
中科院分区：
文献类型：
--
作者：
Buckwalter, Matthew R.;Phan Thi Nga;Albert, Matthew L.
Theiler's murine encephalitis viruses (TMEV) are divided into two subgroups based on their neurovirulence. Persistent strains resemble Theiler's original viruses (referred to as the TO subgroup), which largely induce a subclinical polioencephalomyelitis during the acute phase of the disease and can persist in the spinal cord of susceptible animals, inducing a chronic demyelinating disease. In contrast, members of the neurovirulent subgroup cause an acute encephalitis characterized by the rapid onset of paralysis and death within days following intracranial inoculation. We report herein the characterization of a novel neurovirulent strain of TMEV, identified using pyrosequencing technology and referred to as NIHE. Complete coverage of the NIHE viral genome was obtained, and it shares
