DELINEATION OF THYMIC AND BURSAL LYMPHOID SYSTEMS IN CHICKEN
DELINEATION OF THYMIC AND BURSAL LYMPHOID SYSTEMS IN CHICKEN
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DOI：
10.1038/205143a0
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发表时间：
1965-01-01
期刊：
影响因子：
64.8
通讯作者：
GOOD, RA
中科院分区：
文献类型：
--
作者：
COOPER, MD;PETERSON, RD;GOOD, RA
鸡脾中有两种明显不同的淋巴组织。一种是沿小动脉和小动脉沿着的小淋巴细胞，或由大小淋巴细胞、淋巴母细胞、原始网状细胞组成的散在簇，以及频繁的有丝分裂像。这是脾的白色髓，是脾淋巴组织的主体，在正常鸡刚出壳时就很明显。我们发现在去胸腺照射和去胸腺照射的鸡中，它明显降低。这种消耗以前曾在接受新生儿胸腺切除术的鸡和睾丸激素诱导的胸腺皮质损伤的鸡中观察到。在我们的其他实验组中，这一成分没有显著改变。我们认为这种淋巴组织是鸡的胸腺依赖性淋巴组织。鸡脾脏中还有第二类淋巴组织，无论在形态学上还是在发育时间上都与胸腺依赖型淋巴组织明显不同。可见边界清晰的圆形或椭圆形的淋巴滤泡，被一层薄的纤维膜包裹，并总是与小动脉并列。这些滤泡在形态上与腔上囊的滤泡非常相似（图2）。它们甚至可以更清楚地与其他脾脏成分分离，
In the chicken spleen there are two distinctly different types of lymphoid tissue. One is seen along the small arteries and arterioles, as shcaths of small lymphocytes or as scattered clusters conposed of large and small lymphocytes, lymphoblasts, primitive reticular cells, and frequent mitotic figures, This represents the white pulp of the spleen, the bulk of its lymphoid tissue, and it becomes apparent in normal chickens in the immediate post-hatching period. We found that it was markedly reduced in thymectomized-irradiated and thynaectornizedburscctomized-irradiated chickens. Such depletion has been noted previously in chickens subjected to neonatal surgical thymectomy" and in birds with testosteroneinduced thymic cortical damage?. This component was not significantly altered in our other experimental groups. This lymphoid tissue we consider the thynus-dependent lymphoid tissue of the chicken. There is a second type of lymphoid tissue in the chicken spleen, clearly differentiable from the thyrıus-dependent type both in morphologic appcnranco and in tho time of its development. It is seen as sharply circumscribed round or oval lynphoid follicles (Fig. 1) which seem to be encased by a thin fibrous mcmbranc and which always lie in juxtaposition to a small artery. These follicles bear a striking morphological resemblance to the follicles of the bursa of Fabricius itself (Fig. 2). They are even more clearly separable from the other spleen components when