The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13
The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13
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DOI：
10.1006/geno.1996.0369
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发表时间：
1996-07-15
期刊：
影响因子：
4.4
通讯作者：
Bianchi, ME
中科院分区：
文献类型：
--
作者：
Ferrari, S;Finelli, P;Bianchi, ME
人类基因组中含有大量与高迁移率族1蛋白（HMG 1）cDNA相关的序列，这阻碍了HMG 1基因的克隆和定位。我们发现，人类HMG 1基因含有内含子，而HMG 1相关序列不含内含子，很可能是逆转录假基因，我们从ICI和CEPH文库中鉴定了8个含有人HMG 1基因的YAC。HMG 1基因在结构上与先前表征的鼠同源物相似，并定位于人染色体13带q12，如原位杂交所确定的，小鼠Hmg 1基因定位于小鼠5号染色体的端粒区，该端粒区与人13q12带同线。(C)出版社：Academic Press，Inc.
The human genome contains a large number of sequences related to the cDNA for High Mobility Group 1 protein (HMG1), which so far has hampered the cloning and mapping of the active HMG1 gene, We show that the human HMG1 gene contains introns, while the HMG1-related sequences do not and most likely are retrotransposed pseudogenes, We identified eight YACs from the ICI and CEPH libraries that contain the human HMG1 gene, The HMG1 gene is similar in structure to the previously characterized murine homologue and maps to human chromosome 13 band q12, as determined by in situ hybridization, The mouse Hmg1 gene maps to the telomeric region of murine Chromosome 5, which is syntenic to the human 13q12 band. (C) 1996 Academic Press, Inc.