Ganglion cell layer measurements correlate with disease severity in patients with Alzheimer's disease
Ganglion cell layer measurements correlate with disease severity in patients with Alzheimer's disease
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DOI：
10.1111/aos.12977
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发表时间：
2016-09-01
影响因子：
3.4
通讯作者：
Pablo, Luis E.
中科院分区：
文献类型：
--
作者：
Garcia-Martin, Elena;Bambo, Maria P.;Pablo, Luis E.
目的使用 Spectralis 光学相干断层扫描 (OCT) 的新型分割技术评估阿尔茨海默病 (AD) 患者视网膜 10 层的厚度，并确定特定层的厚度是否可以预测神经退行性变或 AD 严重程度。方法使用分割应用原型对黄斑扫描中的所有视网膜层进行自动分割，对 AD 患者 (n=150) 和年龄匹配的健康对照 (n=75) 进行分析。比较 AD 患者和对照组以及病程小于或至少 3 年的患者之间各层的厚度。评估了视网膜层厚度、疾病持续时间和 AD 严重程度之间的关联。 结果 AD 患者的视网膜神经纤维、神经节细胞、内丛状层和外核层厚度减少 (p
PurposeTo evaluate the thickness of the 10 retinal layers of patients with Alzheimer's disease (AD) using a new segmentation technology of the Spectralis optical coherence tomography (OCT) and to determine whether the thickness of specific layers predicts neurodegeneration or AD severity.MethodsPatients with AD (n=150) and age-matched healthy controls (n=75) were analysed using the segmentation application prototype to automatically segment all retinal layers in a macular scan. Thicknesses of each layer were compared between patients with AD and controls, and between patients with disease durations of less than or at least 3years. Associations between retinal layer thicknesses, disease duration and AD severity were evaluated.ResultsPatients with AD had reduced thickness in the retinal nerve fibre, ganglion cell, inner plexiform and outer nuclear layers (p