Correlation between polymorphism in the inosine triphosphatase and the reductions in hemoglobin concentration and ribavirin dose during sofosbuvir and ribavirin therapy
Correlation between polymorphism in the inosine triphosphatase and the reductions in hemoglobin concentration and ribavirin dose during sofosbuvir and ribavirin therapy
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DOI：
10.1111/jgh.13743
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发表时间：
2017-08-01
影响因子：
4.1
通讯作者：
Tamori, Akihiro
中科院分区：
文献类型：
--
作者：
Kozuka, Ritsuzo;Hai, Hoang;Tamori, Akihiro
背景与目的：目前尚不清楚三磷酸肌苷(ITPA)基因多态性是否与索布韦(SOF)和利巴韦林(RBV)治疗过程中血红蛋白(Hb)浓度降低有关。方法：在106例接受SOF/RBV治疗的慢性丙型肝炎患者中，评估了ITPA基因多态性(Rs1127354)对贫血、RBV剂量减少和持续病毒学应答的影响。结果：106例患者中，80例为CC型，26例为非CC型。在整个治疗过程中，CC基因携带者的Hb浓度下降幅度明显大于非CC基因携带者。有18例(17.0%)患者需要减少RBV剂量，CC基因携带者的发生率显著高于非CC基因携带者(P=0.010)。在多因素分析中，年龄和年龄=65岁(P=0.011)，ITPA CC基因型(P=65岁)。
Background and Aim: It is unclear whether polymorphism in the inosine triphosphatase (ITPA) gene correlates to the reduction in hemoglobin (Hb) concentrations during sofosbuvir (SOF) and ribavirin (RBV) therapy. This study investigated the effects of the ITPA polymorphism on Japanese patients with chronic hepatitis C virus genotype 2 infection treated with SOF/RBV therapy.Methods: In 106 patients treated with SOF/RBV therapy, this study assessed the effects of the ITPA polymorphism (rs1127354) on anemia, RBV dose reduction, and sustained virological response.Results: Of the 106 patients, 80 had the CC genotype, whereas 26 had a non-CC genotype in ITPA. Patients with the CC genotype had significantly larger reductions in Hb concentrations than those with a non-CC genotype throughout the treatment course. RBV dose reduction was required in 18/106 (17.0%) patients, with a significantly higher frequency in patients with the CC genotype than in those with a non-CC genotype (P=0.010). In multivariate analysis, age >= 65 years (P=0.011) and the ITPA CC genotype (P= 65 years.