MicroRNA-29c enhances the sensitivities of human nasopharyngeal carcinoma to cisplatin-based chemotherapy and radiotherapy
MicroRNA-29c enhances the sensitivities of human nasopharyngeal carcinoma to cisplatin-based chemotherapy and radiotherapy
复制标题
MicroRNA-29c增强人鼻咽癌对顺铂化疗和放疗的敏感性
DOI：
10.1016/j.canlet.2012.10.033
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发表时间：
2013-02-01
期刊：
影响因子：
9.7
通讯作者：
Mai, Shi-Juan
中科院分区：
文献类型：
--
作者：
Zhang, Jia-Xing;Qian, Dong;Mai, Shi-Juan
本研究旨在探讨microRNA-29c(miR-29c)在调节鼻咽癌(NPC)对电离辐射(IR)和顺铂敏感性中的潜在作用。在159例鼻咽癌中，miR-29c低表达与耐药呈正相关。我们进一步的体外和体内研究表明，miR-29c的异位修复通过促进细胞凋亡，显著提高了鼻咽癌细胞对IR和顺铂治疗的敏感性。此外，我们还检测到miR-29c抑制了鼻咽癌组织和细胞系中抗凋亡因子Mcl-1和Bcl-2的表达。这些数据表明miR-29c可能成为鼻咽癌治疗的潜在治疗增敏剂。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
This study was aimed to investigate the potential role of microRNA-29c (miR-29c) in regulating the sensitivities of nasopharyngeal carcinoma (NPC) to ionizing radiation (IR) and cisplatin. Low expression of miR-29c was positively associated with therapeutic resistance in 159 NPC cases. Our further in vitro and in vivo studies illustrated ectopic restoration of miR-29c substantially enhanced the sensitivity of NPC cells to IR and cisplatin treatment by promoting apoptosis. Furthermore, we detected miR-29c repressed expression of anti-apoptotic factors, Mcl-1 and Bcl-2 in NPC tissues and cell lines. These data indicate miR-29c might serve as a potential therapeutic sensitizer in NPC treatment. (c) 2012 Elsevier Ireland Ltd. All rights reserved.