Enantioselective Palladium-Catalyzed Carbozincation of Cyclopropenes
Enantioselective Palladium-Catalyzed Carbozincation of Cyclopropenes
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DOI：
10.1021/ol1029904
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发表时间：
2011-02-18
期刊：
影响因子：
5.2
通讯作者：
Lautens, Mark
中科院分区：
文献类型：
--
作者：
Kraemer, Katja;Leong, Paul;Lautens, Mark
研究了钯催化的高对映选择性环丙烯的锌碳加成反应。中间体环丙基锌物种，transmetalation与铜后，被困与各种亲电试剂。这种一锅法提供了具有优异的非对映体和对映体选择性的官能化环丙烯。
A highly enantioselective palladium-catalyzed carbozincation of cyclopropenes has been developed. The intermediate cyclopropylzinc species, after transmetalation with copper, were trapped with various electrophiles. This one-pot procedure furnished functionalizied cyclopropenes with excellent diastereo- and enantioselectivity.