High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer
High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer
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DOI：
10.3892/mco.2016.1088
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发表时间：
2017-01-01
影响因子：
1.2
通讯作者：
Mori, Masaki
中科院分区：
文献类型：
--
作者：
Haraguchi, Naotsugu;Ohara, Nobuyoshi;Mori, Masaki
ADAMTS家族成员包含前肽、金属蛋白酶和去整合素结构域，并且在癌细胞增殖、进展和转移中起关键作用。虽然ADAMTS 5的过表达在胶质母细胞瘤和头颈癌中已有报道，但在结直肠癌类型中几乎没有得到证实。本研究旨在探讨ADAMTS 5在结直肠癌中的表达及其与临床病理因素和预后的关系。检测143例结直肠癌组织中ADAMTS 5 mRNA的表达。ADAMTS 5表达随病理分期的增加而增加。ADAMTS 5在Ⅲ ~ Ⅳ期结直肠癌中的表达显著高于0 ~ Ⅱ期结直肠癌（P=0.0003）。以ADAMTS 5的中位表达分为ADAMTS 5高表达组和ADAMTS 5低表达组，分析ADAMTS 5表达与临床病理因素及预后的关系。ADAMTS 5高表达组的淋巴管浸润和淋巴结转移比例显著高于对照组（P=0.0214和P=0.0289）。通过Kaplan-Meier曲线评估总生存期和无病生存期，并通过对数秩检验计算显著性;然而，在ADAMTS 5高表达组和ADAMTS 5低表达组之间未观察到显著性差异（分别为P=0.7490和P=0.9455）。本研究证实ADAMTS 5的高表达是结直肠癌淋巴管浸润和淋巴结转移的有效标志物。为了阐明ADAMTS 5在结直肠癌中的功能，需要进一步的分子研究。
Members of the ADAMTS family contain propeptide, metalloproteinase and disintegrin domains and serve key roles for cancer cell proliferation, progression and metastasis. Although overexpression of ADAMTS5 has been reported in glioblastoma, and head and neck cancer, little has been demonstrated in colorectal cancer types. The present study aimed to clarify the significance of ADAMTS5 for clinicopathological factors and prognosis in colorectal cancer. The mRNA expression of ADAMTS5 was measured in 143 colorectal cancer specimens. ADAMTS5 expression was increased as the pathological stage increased. The expression of ADAMTS5 in stage III-IV colorectal cancer was significantly greater compared with that of stage 0-II colorectal cancer (P=0.0003). The median expression of ADAMTS5 was used to divide the ADAMTS5 higher expressing group and the ADAMTS5 lower expressing group to assess the correlation of ADAMTS5 expression with clinicopathological factors and prognosis. The proportions of lymphatic invasion and lymph node metastasis were significantly greater in the ADAMTS5 higher expressing group (P=0.0214 and P=0.0289 respectively). Overall survival and disease-free survival were assessed by the Kaplan-Meier curve with calculation of significance by the log-rank test; however, no significant difference was observed between the ADAMTS5 higher expressing group and the ADAMTS5 lower expressing group (P=0.7490 and P=0.9455, respectively). The present study confirmed high expression of ADAMTS5 as a potent marker for lymphatic invasion and lymphnode metastasis in colorectal cancer. To clarify the function of ADAMTS5 in colorectal cancer, further molecular investigations are required.