Brain N-acetyl aspartate concentrations measured by H MRS are reduced in adult male rats subjected to perinatal stress: preliminary observations and hypothetical implications for neurodevelopmental disorders.
Brain N-acetyl aspartate concentrations measured by H MRS are reduced in adult male rats subjected to perinatal stress: preliminary observations and hypothetical implications for neurodevelopmental disorders.
复制标题
在遭受围产期应激的成年雄性大鼠中，通过 H MRS 测量的脑 N-乙酰天冬氨酸浓度降低：初步观察和对神经发育障碍的假设影响。
DOI：
10.1016/s0022-3956(98)00043-0
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发表时间：
1999
影响因子：
4.8
通讯作者：
Ernst,T
中科院分区：
文献类型：
--
作者：
Poland,RE;Cloak,C;Lutchmansingh,PJ;McCracken,JT;Chang,L;Ernst,T
本研究旨在确定围产儿应激期成年大鼠脑内n -乙酰-天冬氨酸（NAA）（一种被认为是神经元标记物）的浓度是否降低。从妊娠第14 ~ 21天起，以妊娠大鼠为产前应激源，每天2次，每次1小时；应激后代由正常母鼠饲养，成年后进行研究。以正常幼鼠为产后应激源，用产前应激母鼠饲养成年幼鼠进行研究。与非应激对照组（n=6）相比，产前应激组（n=4）和产后应激组（n=6）左额叶皮层NAA浓度分别显著降低21%和25%。数据表明，围产期应激的成年后代发生了永久性的神经元损伤或丧失。虽然从这些有限的数据中无法推断出围产期应激与特定疾病发展之间的直接因果关系，但本文综述了围产期应激对随后脑神经病理的影响，特别是与NAA有关的影响。为了产生假设的目的，压力和NAA对精神分裂症神经发育假说的可能相关性进行了更详细的讨论。
The present study was undertaken to determine if the concentration of brain N-acetyl-aspartate (NAA), a putative neuronal marker, is reduced in adult rats subjected to stress during the perinatal period. As the prenatal stressor, pregnant rats were subjected to restraint stress for one hour twice daily from days 14–21 of gestation; stressed offspring were reared by normal dams and studied as adults. As the postnatal stressor, normal pups were reared by prenatally stressed dams and studied as adults. As compared to non-stressed controls (n=6), NAA concentrations were significantly reduced 21 and 25% in left frontal cortex from the prenatal (n=4) and postnatal (n=6) stress groups, respectively. The data suggest that in perinatally stressed adult offspring permanent neuronal damage or loss has occurred. While no direct causal associations between perinatal stress and the developmental of particular disorders can be inferred from these limited data, the effects of perinatal stress on subsequent brain neuropathology are reviewed, particularly in relation to NAA. For hypothesis-generating purposes, the possible relevance of stress and NAA to the neurodevelopmental hypothesis of schizophrenia is discussed in greater detail.