TUMOR-CELL LOCOMOTION - FACTOR IN METASTASIS FORMATION - INFLUENCE OF CYTOCHALASIN-B ON A TUMOR DISSEMINATION PATTERN
TUMOR-CELL LOCOMOTION - FACTOR IN METASTASIS FORMATION - INFLUENCE OF CYTOCHALASIN-B ON A TUMOR DISSEMINATION PATTERN
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DOI：
10.1002/ijc.2910190419
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发表时间：
1977-01-01
影响因子：
6.4
通讯作者：
RYD, W
中科院分区：
文献类型：
--
作者：
HAGMAR, B;RYD, W
在体内研究细胞松弛素B（CB）对TA 3腹水[小鼠乳腺]肿瘤细胞的影响，以评估CB诱导的细胞麻痹是否会影响细胞的移植行为，特别是静脉内细胞输注后的肿瘤分布（实验转移）。用CB（1 μ g/ml）预处理肿瘤细胞不改变s.c.或TA3细胞的静脉内可移植性。用10 μ g/ml CB预处理一致地增加了从静脉内输注的细胞获取的肺外肿瘤的发生率和数量。肺肿瘤的数量没有显著改变。S.C.可移植性不受10 μ g/ml CB的影响。细胞的流动性和细胞表面形貌的重要性，肿瘤细胞在血管中的nidation进行了讨论。
The influence of cytochalasin B (CB) on TA3 ascites [mouse mammary] tumor cells was in vivo to assess whether CB induced cell paralysis would affect the transplantation behavior of the cells and in particular tumor distribution after i.v. cell infusion (experimental metastases). Tumor cell pretreatment with CB (1 .mu.g/ml) did not alter the s.c. or i.v. transplantability of TA3 cells. Pretreatment with 10 .mu.g/ml CB, consistently increased the incidence and number of extrapulmonary tumor takes from i.v. transfused cells. The amount of pulmonary tumors was not significantly altered. S.c. transplantability was not affected by 10 .mu.g/ml CB. The importance of cell mobility and cell surface topography for tumor cell nidation in vessels is discussed.