Trypsin inhibition by mouse serum: sexual dimorphism controlled by testosterone.
Trypsin inhibition by mouse serum: sexual dimorphism controlled by testosterone.
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小鼠血清的胰蛋白酶抑制：睾酮控制的性二态性。
DOI：
10.1126/science.6849130
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发表时间：
1983
期刊：
影响因子：
56.9
通讯作者：
J. Mills
中科院分区：
文献类型：
--
作者：
F. Kueppers;J. Mills
雄性小鼠血清中的胰酶抑制活性显著高于雌性小鼠。在五个品系的小鼠和两大品系间杂交的小鼠中，这一差异从14%(ICR小鼠)到55%(DBA小鼠)不等。雄性去势显著降低了血清胰酶抑制活性，而睾酮的注射使其活性恢复到原来的水平。给雌性小鼠注射睾丸素后，这种活动增加到与同品系雄性小鼠相似的水平。因为几乎所有抑制活性的变化都发生在电泳区的α-1区，所以α-1-抗胰蛋白酶可能是这种作用的原因。
The trypsin inhibiting activity in the serum of male mice is substantially greater than that in females. In five strains of mice and two large groups of interstrain hybrids this difference ranged from 14 (in ICR mice) to 55 percent (in DBA mice). Castration of males significantly decreased the serum trypsin inhibiting activity, whereas the administration of testosterone restored the activity to its original level. Administration of testosterone to female mice increased the activity to a level similar to that in males of the same strain. Because almost all the change in inhibiting activity occurred in the electrophoretic alpha-1 region, alpha-1 region, alpha-1-antitrypsin is probably responsible for this effect.