DES-GAMMA-CARBOXY (ABNORMAL) PROTHROMBIN AS A SERUM MARKER OF PRIMARY HEPATOCELLULAR-CARCINOMA
DES-GAMMA-CARBOXY (ABNORMAL) PROTHROMBIN AS A SERUM MARKER OF PRIMARY HEPATOCELLULAR-CARCINOMA
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DOI：
10.1056/nejm198405313102204
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发表时间：
1984-01-01
影响因子：
158.5
通讯作者：
FURIE, B
中科院分区：
文献类型：
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作者：
LIEBMAN, HA;FURIE, BC;FURIE, B
经病理证实的76例肝细胞癌患者中，69例(91%)血清中检出异常凝血酶原酶，平均为900 ng/ml。慢性活动性肝炎患者(平均10 ng/ml)和肝转移癌患者(平均42 ng/ml)的异常凝血酶原水平较低，而正常人则检测不到。接受维生素K治疗的5例患者的异常凝血酶原无下降，表明其存在不是由于维生素K缺乏所致。2例手术切除肿瘤和1例化疗显著降低了异常凝血酶原浓度，后来在疾病复发时增加。血清甲胎蛋白水平与异常凝血酶原水平相关性较差。异常凝血酶原检测和甲胎蛋白检测共同确定了76例肝癌患者中的(84%)。凝血酶原异常对原发性肝细胞癌的实验室诊断有一定价值。
Des-.gamma.-carboxy prothrombin, an abnormal prothrombin was detected in the serum of 69 of 76 patients (91%) with biopsy-confirmed hepatocellular carcinoma (the mean level of the abnormal prothrombin was 900 ng/ml). Levels of the abnormal prothrombin were low in patients with chronic active hepatitis (mean, 10 ng/ml) or metastatic carcinoma involving the liver (mean, 42 ng/ml) and undetectable in normal subjects. In 5 patients treated with vitamin K there was no reduction in abnormal prothrombin, indicating that its presence was not due to vitamin K deficiency. Surgical resection of tumors in 2 patients and chemotherapy in 1 patient markedly reduced abnormal-prothrombin concentrations, which later increased in recurrence of disease. Serum .alpha.-fetoprotein levels correlated poorly with abnormal-prothrombin levels. Together, the assay for abnormal prothrombin and the .alpha.-fetoprotein assay identified 64 of 76 patients with hepatoma (84%). Abnormal prothrombin may be useful in the laboratory diagnosis of primary hepatocellular carcinoma.