Lessons From Outbreaks of H1N1 Influenza
Lessons From Outbreaks of H1N1 Influenza
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DOI：
10.7326/0003-4819-151-1-200907070-00123
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发表时间：
2009-07-07
影响因子：
39.2
通讯作者：
Stein, Richard A.
中科院分区：
文献类型：
--
作者：
Stein, Richard A.
最近，在来自美国和墨西哥的出现呼吸道症状的个体中发现了一种新的 H1N1 三重重组“猪”流感病毒，随后在世界多个国家的患者中也证实了这种病毒。这种病原体出现的环境以及促进最初跨物种传播的因素仍不完全清楚。在疫情爆发初期，人们就发现该病毒可以在人与人之间直接传播。起源于动物宿主并随后具有人际传播潜力的病原体在人类历史上曾引起过疫情爆发。尽管每次疫情都有其特殊性，但重要的是要记住以前的流行病和大流行病的教训。整合过去的重要教训将为了解宿主与病原体的相互作用提供最佳机会，并为实施有效的预防和治疗措施提供最有力的方法。
A new H1N1 triple-reassortant "swine" influenza virus was recently described in individuals from the United States and Mexico who presented with respiratory symptoms, and the same virus was subsequently confirmed in patients from several countries around the world. The circumstances surrounding the emergence of this pathogen, and the factors that facilitated the initial cross-species transmission, are still incompletely understood. It became apparent in the early days of the outbreak that the virus can be directly transmitted between humans. Pathogens that originate in animal reservoirs and subsequently acquire the potential for human-to-human transmission have caused outbreaks throughout human history. Although each outbreak is marked by its own particularities, it is important to remember the teachings that emerge from previous epidemics and pandemics. Integrating the important lessons of the past will provide the best opportunity to understand host-pathogen interaction and the most powerful approach to implementing effective prophylactic and therapeutic measures.