Ma’edamines C and D, New Bromotyrosine Alkaloids Possessing a Unique Tetrasubstituted Pyridinium Moiety from an Okinawan Marine Sponge Suberea sp.
Ma’edamines C and D, New Bromotyrosine Alkaloids Possessing a Unique Tetrasubstituted Pyridinium Moiety from an Okinawan Marine Sponge Suberea sp.
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Ma’edamines C 和 D，新型溴酪氨酸生物碱，具有来自冲绳海洋海绵 Suberea sp 的独特四取代吡啶部分。
DOI：
10.1021/acs.orglett.9b03457
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Kubota Takaaki
中科院分区：
文献类型：
--
作者：
Kurimoto Shin-ichiro;Seino Satsuki;Fromont Jane;Kobayashi Jun’ichi;Kubota Takaaki
从冲绳海绵 Suberea sp. 中分离出两种新的溴酪氨酸生物碱，ma'edamines C 和 D。根据光谱数据阐明了 ma'edamines C 和 D 的结构。 Ma'edamines C和D是第一个具有独特四取代吡啶部分的天然产物，分别为N-烷基-3,5-二乙基-2-丙基吡啶和N-烷基-3,5-二乙基-4-丙基吡啶。 Ma'edamines C 和 D 在体外对鼠白血病细胞系 L1210 表现出中等的细胞毒性。
Two new bromotyrosine alkaloids, ma'edamines C and D, were isolated from an Okinawan marine sponge Suberea sp. The structures of ma'edamines C and D were elucidated on the basis of spectroscopic data. Ma'edamines C and D were the first natural products possessing a unique tetrasubstituted pyridinium moiety such as N-alkyl-3, 5-diethyl-2-propylpyridinium and N-alkyl-3, 5-diethyl-4-propylpyridinium, respectively. Ma'edamines C and D exhibited moderate cytotoxicity against murine leukemia cell line L1210 in vitro.