Nociceptin modulates renal sympathetic nerve activity through a central action in conscious rats.
Nociceptin modulates renal sympathetic nerve activity through a central action in conscious rats.
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痛敏肽通过清醒大鼠的中枢作用调节肾交感神经活动。
DOI：
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发表时间：
1999
影响因子：
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通讯作者：
H. Kannan
中科院分区：
文献类型：
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作者：
T. Shirasaka;T. Kunitake;Kazuo Kato;M. Takasaki;H. Kannan
孤啡肽是阿片样受体样（1）受体的内源性激动剂，在下丘脑中表达，参与自主神经系统控制。然而，孤啡肽对交感神经活动的中枢作用尚未研究。我们研究了侧脑室注射痛敏素（2-10 nmol）对清醒大鼠和去sinocellular神经支配（SAD）大鼠血压、心率（HR）和肾交感神经活动（RSNA）的影响。侧脑室注射伤害感受素可使大鼠的平均动脉压（MAP）和心率呈剂量依赖性下降。在2和5 nmol剂量下，RSNA分别降低31.5 +/- 2.1和19.9 +/- 5.0%。SAD大鼠的MAP、HR和RSNA呈剂量依赖性下降，最大反应大于正常大鼠。痛敏素诱导的HR降低可被普萘洛尔阻断，但不能被阿托品阻断，这表明痛敏素通过抑制心脏交感神经流出而起作用。这些痛敏素诱导的降压和心动过缓反应，不拮抗预处理纳洛酮和nocistatin。这些发现表明中枢痛敏素可能在调节心血管和交感神经系统方面具有功能作用。
Nociceptin, an endogenous agonist of the opioid receptor-like(1) receptor, is expressed in the hypothalamus, where it is implicated in autonomic nervous system control. However, the central actions of nociceptin on sympathetic nerve activity have not been studied. We investigated the effect of intracerebroventricularly administered nociceptin (2-10 nmol) on blood pressure, heart rate (HR), and renal sympathetic nerve activity (RSNA) in conscious rats and sinoaortic-denervated (SAD) rats. Intracerebroventricularly administered nociceptin resulted in a dose-dependent decrease in mean arterial pressure (MAP) and HR in intact rats. RSNA decreased 31.5 +/- 2.1 and 19.9 +/- 5.0% at a dose of 2 and 5 nmol, respectively. In SAD rats, MAP, HR, and RSNA decreased in a dose-dependent manner, and the maximum responses were larger than those in intact rats. The decrease in HR induced by nociceptin was blocked by propranolol but not by atropine, which indicates that nociceptin is acting by inhibiting cardiac sympathetic outflow. These nociceptin-induced depressor and bradycardic responses were not antagonized by pretreatment with naloxone and nocistatin. These findings suggest that central nociceptin may have a functional role in regulating cardiovascular and sympathetic nervous systems.