Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
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DOI：
10.1038/s41541-020-00221-3
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发表时间：
2020-07-27
期刊：
影响因子：
9.2
通讯作者：
Lambe, Teresa
中科院分区：
文献类型：
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作者：
Graham, Simon P.;McLean, Rebecca K.;Lambe, Teresa
COVID-19候选疫苗ChAdOx 1 nCoV-19（一种表达全长SARS-CoV-2刺突蛋白的复制缺陷型猿猴腺病毒载体）的临床开发于2020年4月启动，此前使用单次免疫进行了非人类灵长类动物研究。在这里，我们比较了一个或两个剂量的ChAdOx 1 nCoV-19在小鼠和猪中的免疫原性。虽然单剂量诱导抗原特异性抗体和T细胞应答，但加强免疫增强了抗体应答，特别是在猪中，SARS-CoV-2中和滴度显著增加。
Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres.