Extended virulence genotypes and phylogenetic background of Escherichia coli isolates from patients with cystitis, pyelonephritis, or prostatitis
Extended virulence genotypes and phylogenetic background of Escherichia coli isolates from patients with cystitis, pyelonephritis, or prostatitis
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DOI：
10.1086/426450
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发表时间：
2005-01-01
影响因子：
6.4
通讯作者：
Vila, J
中科院分区：
文献类型：
--
作者：
Johnson, JR;Kuskowski, MA;Vila, J
对63株大肠杆菌尿液分离株的分子分析表明，肾盂肾炎（n = 9）和前列腺炎（n = 17）分离株在所检测的35种毒力因子（VFs）中，比膀胱炎分离株（n = 23）表现出更多的毒力因子。几种非传统毒力因子——包括bmaE（M菌毛）、gafD（G菌毛）、fyuA（耶尔森杆菌素受体）、ireA和iroN（新型铁载体受体）、cvaC（大肠杆菌素[小菌素]V）、traT（血清抗性相关）、ibeA（脑内皮细胞侵袭）、ompT（外膜蛋白酶T）和malX（致病岛标记）——要么在不同综合征之间有显著差异（尽管分离株数量少且可能存在多重比较假象），要么广泛流行。因此，尽管可能存在综合征特异性发病机制和/或宿主防御系统，但针对保守的尿路毒力因子的干预措施是可能的。
Molecular analysis of 63 Escherichia coli urine isolates showed that pyelonephritis () and prostatitis (n = 17) isolates exhibited more virulence factors (VFs) among the 35 sought than did cystitis isolates (n = 23). Several nontraditional VFs-including bmaE (M fimbriae), gafD (G fimbriae), fyuA (yersiniabactin receptor), ireA and iroN (novel siderophore receptors), cvaC (colicin [microcin] V), traT (serum-resistance associated), ibeA (invasion of brain endothelium), ompT (outer membrane protease T), and malX (pathogenicity island marker)-either differentiated significantly between syndromes (despite small numbers of isolates and possible multiple-comparison artifacts) or were broadly prevalent. Thus, interventions that target conserved uro-VFs may be possible, despite the likely existence of syndrome-specific pathogenetic mechanisms and/or host defense systems.