Cytotoxic and antimicrobial metabolites from marine lignicolous fungi, Diaporthe sp.
Cytotoxic and antimicrobial metabolites from marine lignicolous fungi, Diaporthe sp.
复制标题
DOI：
10.1016/j.femsle.2005.07.025
复制
发表时间：
2005-10-01
影响因子：
2.1
通讯作者：
Su, WJ
中科院分区：
文献类型：
--
作者：
Lin, X;Huang, YJ;Su, WJ
从一种新的细菌Diaporthe sp.的培养物中分离得到一个新化合物（1），命名为diaporthelactone，一种生长在福建福贡红树林自然保护区秋茄腐叶中的海洋真菌。新化合物经鉴定为1，3-二氢-4-甲氧基-7-甲基-3-氧代-5-异苯并呋喃甲醛（1），对KB和Raji细胞系显示出细胞毒活性（IC_（50）分别为6.25和5.51 μ G·mL ~（-1））。两个已知化合物7-甲氧基-4，6-二甲基-3H-异苯并呋喃-1-酮（2）和真菌环氧二烯（3）也首次被证实具有细胞毒活性。对所有三种化合物的抗微生物活性进行了评估。(c)2005年，欧洲微生物学会联合会。Elsevier B. V.出版，保留所有权利。
A new compound (1), named diaporthelactone, together with two known compounds (2 and 3) were isolated from the culture of Diaporthe sp., a marine fungus growing in the submerged rotten leaves of Kandelia candel in the mangrove nature conservation areas of Fugong, Fujian Province of China. The new compound was elucidated to be 1,3-dihydro-4-methoxy-7methyl-3-oxo-5-isobenzofuran-carboxyaldehyde (1), which showed cytotoxic activity against KB and Raji cell lines (IC50 6.25 and 5.51 mu G mL(-1), respectively). Two known compounds, 7-methoxy-4,6-dimethyl-3H-isobenzofuran-1-one (2) and mycoepoxydiene (3), were also demonstrated to exhibit cytotoxic activities for the first time. All three compounds were assessed for antimicrobial activity. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.