Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: A population-based study
Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: A population-based study
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DOI：
10.1016/j.autneu.2007.08.002
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发表时间：
2007-12-30
影响因子：
2.7
通讯作者：
Reeves, William C.
中科院分区：
文献类型：
--
作者：
Boneva, Roumiana S.;Decker, Michael J.;Reeves, William C.
慢性疲劳综合征（CFS）患者存在自主神经系统（ANS）功能障碍。在这项研究中，我们试图确定CFS患者在清醒期间观察到的心率（HR）增加和心率变异性（HRV）降低的参数是否在睡眠期间持续存在。为此，我们在一项以人群为基础的病例对照研究中比较了CFS受试者和非疲劳（NF）对照者的心率（HR）和HRV作为ANS功能指标。30例CFS受试者和38例NF对照者，年龄、性别和体重指数匹配，有资格进行分析。主要结果指标包括平均RR间期（RRI）、HR和来自夜间ECG的HRV参数。血浆醛固酮和去甲肾上腺素水平，药物与心血管效应，并报告体力活动作为协变量进行了检查。一般线性模型用于评估关联的显著性并调整潜在混杂因素。与对照组相比，CFS患者的平均HR显著升高（71.4 vs 64.8 bpm），平均RRI较短[840.4（85.3）vs 925.4（97.8）ms]（p
Autonomic nervous system (ANS) dysfunction has been suggested in patients with chronic fatigue syndrome (CFS). In this study, we sought to determine whether increased heart rate (HR) and reduced heart rate variability (HRV) parameters observed in CFS patients during wakefulness persist during sleep. To this end, we compared heart rate (HR) and HRV as indicators of ANS function in CFS subjects and nonfatigued (NF) controls in a population-based, case-control study. Thirty subjects with CFS and 38 NF controls, matched for age-, sex- and body mass index, were eligible for analysis. Main outcome measures included mean RR interval (RRI), HR, and HRV parameters derived from overnight ECG. Plasma aldosterone and norepinephrine levels, medicines with cardiovascular effect, and reported physical activity were examined as covariates. General Linear Models were used to assess significance of associations and adjust for potential confounders. Compared to controls, CFS cases had significantly higher mean HR (71.4 vs 64.8 bpm), with a shorter mean RRI [840.4 (85.3) vs 925.4 (97.8) ms] (p