Seventeen-point dermal ultrasound scoring system - a reliable measure of skin thickness in patients with systemic sclerosis
Seventeen-point dermal ultrasound scoring system - a reliable measure of skin thickness in patients with systemic sclerosis
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DOI：
10.1093/rheumatology/keg435
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发表时间：
2003-12-01
期刊：
影响因子：
5.5
通讯作者：
Herrick, AL
中科院分区：
文献类型：
--
作者：
Moore, TL;Lunt, M;Herrick, AL
Objective.我们的目的是开发一种17个部位的超声测量系统性硬化症（SSc）患者皮肤厚度的方法，并评估其观察者间和观察者内的变异性。在39例SSc患者（26例局限性皮肤，13例弥漫性）和34例健康对照者的17个部位（对应于改良Rodnan皮肤评分中评估的部位）测量皮肤厚度（使用22 MHz超声探头）。还记录了厚度总和（17个部位）和最大厚度。由于不同部位的皮肤厚度不同，因此将每次测量值转换为z评分。分别在35例患者/33例对照和20例患者/15例对照中评估观察者间和观察者内变异性。皮肤测量的测量精度良好，17个部位的观察者间变异性（最大厚度为0.86）和观察者内变异性（最大厚度为0.92）的组内相关系数范围为0.65至0.94。我们的研究结果表明，17点皮肤超声评分系统是非常可靠的，因此可能是一个有用的措施，包括在临床试验的结果。
Objective. Our objective was to develop a 17-site ultrasound method of measuring skin thickness in patients with systemic sclerosis (SSc) and to assess its inter- and intra-observer variability.Methods. Dermal thickness (using a 22 MHz ultrasound probe) was measured at 17 sites (corresponding to those assessed in the modified Rodnan skin score) in 39 patients with SSc (26 limited cutaneous, 13 diffuse) and 34 healthy controls. The sum of the thicknesses (at the 17 sites) and the maximal thickness were also documented. Because skin thickness varies between sites, each measurement was converted to a z-score. Inter- and intra-observer variability were assessed in 35 patients/33 controls, and 20 patients/15 controls respectively.Results. Measurement precision was good for the dermal measurements-intraclass correlation coefficients at the 17 sites ranged from 0.65 to 0.94 for the inter-observer variability (0.86 for maximum thickness) and from 0.55 to 0.96 for the intra-observer variability (0.92 for maximum thickness).Conclusion. Our results suggest that the 17-point dermal ultrasound scoring system is extremely reliable and may therefore be a useful measure of outcome, including in clinical trials.