Iron uptake and release by macrophages is sensitive to propranolol.
Iron uptake and release by macrophages is sensitive to propranolol.
复制标题
巨噬细胞对铁的吸收和释放对普萘洛尔敏感。
DOI：
10.1007/s11010-006-9138-2
复制
发表时间：
2006
影响因子：
4.3
通讯作者：
Weglicki,WilliamB
中科院分区：
文献类型：
--
作者：
Komarov,AndreiM;Hall,JonathonM;Chmielinska,JoannaJ;Weglicki,WilliamB
In this study we have tested the effects ofd-propranolol (D-Pro) on the iron uptake, iron release and oxidative response of iron-loaded cells in a cellular model of iron-overload using isolated rat peritoneal macrophages incubated with iron-dextran (Fe-D). Pretreatment of macrophages with D-Pro (5–200 μ M) prior to Fe-D exposure decreased the cellular iron content and partially prevented iron release from latex-activated macrophages. Release of reactive oxygen species from activated cells was detected by dichlorodihydrofluorescein (DCDHF, 5 μ M) oxidation. We found that loading cells with Fe-D increased their response to latex, which was prevented by the lysosomotropic antioxidant agent D-Pro (10 μ M).
