SPECIFIC ROLES FOR PLATELET SURFACE GLYCOPROTEINS IN PLATELET-FUNCTION
SPECIFIC ROLES FOR PLATELET SURFACE GLYCOPROTEINS IN PLATELET-FUNCTION
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DOI：
10.1038/255720a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
CAEN, JP
中科院分区：
文献类型：
--
作者：
NURDEN, AT;CAEN, JP
血小板的止血作用在很大程度上取决于其在血管损伤时粘附于暴露的内皮下成分的能力1，以及对特异性聚集诱导刺激（如二磷酸腺苷（ADP），其似乎作用于血小板膜上确定的受体位点2）的反应。血小板粘附和聚集的早期阶段是表面介导的现象，许多兴趣集中在确定哪些表面分组参与这些机制。碘化技术3，4揭示了血小板表面暴露的蛋白质数量有限，其中包括主要的膜糖蛋白。Mesteret等人5描述了ADP和5-羟色胺诱导的聚集机制中可能涉及碳水化合物基团，他表明血小板唾液酸含量的变化会改变聚集速度。
THE haemostatic role of the blood platelet is largely dependent on its ability to adhere to exposed subendothelial components in the event of vessel damage1and respond to specific aggregation-inducing stimuli, such as adenosine diphosphate (ADP), which seem to act at defined receptor sites on the platelet membrane2. The early stages of platelet adhesion and aggregation are surface-mediated phenomena and much interest has centred on determining which of the surface groupings are involved in these mechanisms. Iodination techniques3,4have revealed that a limited number of proteins are exposed on the surface of the platelet and that among these are the major membrane glycoproteins. A possible involvement of carbohydrate groupings in the mechanisms of aggregation as induced by ADP and 5-hydroxytryptamine was described by Mesteret al.5who showed that the velocity of aggregation was altered by changes in the sialic acid content of the platelet.