Naturally occurring anti-band 3 antibodies and red blood cell removal under physiological and pathological conditions
Naturally occurring anti-band 3 antibodies and red blood cell removal under physiological and pathological conditions
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DOI：
10.1016/j.autrev.2008.03.017
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发表时间：
2008-06-01
影响因子：
13.6
通讯作者：
Turrini, Franco
中科院分区：
文献类型：
--
作者：
Pantaleo, Antonella;Giribaldi, Giuliana;Turrini, Franco
针对带3蛋白（主要红细胞膜蛋白）的天然存在的抗体（NAb）参与红细胞（RBC）在其寿命结束时的清除以及在不同遗传性溶血性疾病和疟疾中RBC的去除。在所有引用的情况下，RBC经历氧化应激并形成血红素（血红蛋白降解产物）。半色素对带3胞质结构域具有强亲和力，并且在它们结合之后，导致带3氧化和簇合。这些条带3簇显示出对NAb的亲和力增加，NAb激活补体并最终触发改变的RBC的吞噬作用。在红细胞内疟疾寄生虫生长期间，NAb开始在早期寄生虫发育阶段与RBC表面结合，增加它们的丰度，与寄生虫发育平行。有趣的是，已知对疟疾发挥保护作用的许多遗传性溶血性疾病往往会加剧这种现象，导致疟疾寄生虫感染的患病RBC的更早熟和有效的调理作用。带3新抗原的确切定义及其表面暴露的机制仍不清楚。此外，带3簇化仅被肤浅地理解，关于带3由Sre激酶磷酸化的新见解表明存在复杂的调节途径。(C)2008 Elsevier B.V.保留所有权利。
Naturally occurring antibodies (NAbs) directed to band 3 protein (major erythrocyte membrane protein) are involved in the clearance of red blood cell (RBC) at the end of their lifespan as well as in the removal of RBC in different hereditary haemolytic disorders and in malaria. In all cited situations RBC undergoes oxidative stress and hemichromes (haemoglobin degradation products) are formed. Hemichromes possess a strong affinity for band 3 cytoplasmic domain and, following their binding, lead to band 3 oxidation and clusterisation. Those band 3 clusters show increased affinity for NAbs which activate complement and finally trigger the phagocytosis of altered RBC. During intra-erythrocytic malaria parasite growth, NAbs begin to bind to RBC surface at early parasite development stages increasing their abundance in parallel with parasite development. Interestingly, a number of hereditary haemolytic disorders, known to exert a protective effect on malaria, tend to exacerbate this phenomenon leading to a more precocious and effective opsonization of diseased RBC infected by malaria parasites. The exact definition of band 3 neo-antigens and the mechanism of their surface exposure are still unclear. Also band 3 clusterisation is only superficially understood, new insights about band 3 phosphorylation by Sre kinases suggest the presence of a complex regulatory pathway. (C) 2008 Elsevier B.V. All rights reserved.