Growth control in the proliferative region of the Drosophila eye-head primordium:: The elbow-noc gene complex
Growth control in the proliferative region of the Drosophila eye-head primordium:: The elbow-noc gene complex
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DOI：
10.1016/j.ydbio.2006.07.050
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发表时间：
2007-01-15
影响因子：
2.7
通讯作者：
Milan, Marco
中科院分区：
文献类型：
--
作者：
Luque, Carlos M.;Milan, Marco
Notch 信号传导参与细胞分化和模式形成，以及生长和细胞存活的调节。果蝇眼头原基背腹边界的 Notch 激活导致分泌蛋白 Unpaired 的表达，Unpaired 是 JAK-STAT 途径的配体，可诱导未分化组织中的细胞增殖。由肘和无单眼编码的锌指蛋白在眼头原基的高度增殖区域表达。肘部丧失和单眼无活动会导致头囊过度生长，但不会从头诱导 Upd 表达。这些过度生长依赖于Notch活性，表明肘部和noc抑制了Notch在驱动细胞增殖中的独立于Upd的作用。当过度生长的组织尺寸增大时，可以发现异位触角和眼睛结构。因此，通过肘部和无单眼严格调节眼头原基的大小对于正确的命运规范和成人结构的生成至关重要。 (c) 2006 Elsevier Inc. 保留所有权利。
Notch signaling is involved in cell differentiation and patterning, as well as in the regulation of growth and cell survival. Notch activation at the dorsal-ventral boundary of the Drosophila eye-head pritnordium leads to the expression of the secreted protein Unpaired, a ligand of the JAK-STAT pathway that induces cell proliferation in the undifferentiated tissue. The zinc finger proteins encoded by elbow and no ocelli are expressed in the highly proliferative region of the eye-head primordium. Loss of elbow and no ocelli activities induces overgrowths of the head capsule, without inducing Upd expression de novo. These overgrowths depend on Notch activity suggesting that elbow and noc repress a Upd independent role of Notch in driving cell proliferation. When the size of the overgrown tissue is increased, ectopic antenna and eye structures can be found. Thus, tight regulation of the size of the eye-head primordium by elbow and no ocelli is crucial for proper fate specification and generation of the adult structures. (c) 2006 Elsevier Inc. All rights reserved.