Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis
Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis
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DOI：
10.3945/ajcn.112.037556
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发表时间：
2012-12-01
影响因子：
7.1
通讯作者：
van Loon, Luc J. C.
中科院分区：
文献类型：
--
作者：
Cermak, Naomi M.;Res, Peter T.;van Loon, Luc J. C.
背景：单次阻力型运动后的蛋白质摄入会刺激运动后急性恢复过程中的净肌肉蛋白积累。因此，人们普遍认为需要补充蛋白质来最大限度地提高骨骼肌对长时间阻力型运动训练的适应性反应。然而，文献中关于年轻和老年人群长期阻力型运动训练期间补充蛋白质的益处存在很大差异。目的：本研究的目的是确定补充蛋白质以增强年轻和老年人群骨骼肌对长期阻力型运动训练的适应性反应的功效。设计：通过使用随机效应荟萃分析模型对干预证据进行系统评价。结果变量无脂体重 (FFM)、脂肪量、I 型和 II 型肌纤维横截面积以及 1 次最大重复 (1-RM) 腿部按压力量的数据来自随机对照试验 (RCT)，这些试验调查了膳食蛋白质补充剂在长时间（>6 周）阻力型运动训练期间的影响。结果：数据来自 22 项 RCT，其中包括 680 名受试者。在年轻人和老年人中进行长期阻力型运动训练后，与安慰剂相比，补充蛋白质对 FFM（加权平均差：0.69 kg；95% CI：0.47，0.91 kg；P < 0.00001）和 1-RM 腿举力量（加权平均差：13.5 kg；95% CI：6.4，20.7 kg；P < 0.005）有积极作用结论：无论是年轻还是年长的受试者，在长时间的阻力型运动训练中，补充蛋白质都会增加肌肉质量和力量增益。美国临床营养杂志 2012；96：1454-64。
Background: Protein ingestion after a single bout of resistance-type exercise stimulates net muscle protein accretion during acute postexercise recovery. Consequently, it is generally accepted that protein supplementation is required to maximize the adaptive response of the skeletal muscle to prolonged resistance-type exercise training. However, there is much discrepancy in the literature regarding the proposed benefits of protein supplementation during prolonged resistance-type exercise training in younger and older populations.Objective: The objective of the study was to define the efficacy of protein supplementation to augment the adaptive response of the skeletal muscle to prolonged resistance-type exercise training in younger and older populations.Design: A systematic review of interventional evidence was performed through the use of a random-effects meta-analysis model. Data from the outcome variables fat-free mass (FFM), fat mass, type I and II muscle fiber cross-sectional area, and 1 repetition maximum (1-RM) leg press strength were collected from randomized controlled trials (RCTs) investigating the effect of dietary protein supplementation during prolonged (>6 wk) resistance-type exercise training.Results: Data were included from 22 RCTs that included 680 subjects. Protein supplementation showed a positive effect for FFM (weighted mean difference: 0.69 kg; 95% CI: 0.47, 0.91 kg; P < 0.00001) and 1-RM leg press strength (weighted mean difference: 13.5 kg; 95% CI: 6.4, 20.7 kg; P < 0.005) compared with a placebo after prolonged resistance-type exercise training in younger and older subjects.Conclusion: Protein supplementation increases muscle mass and strength gains during prolonged resistance-type exercise training in both younger and older subjects. Am J Clin Nutr 2012;96:1454-64.