Serum BDNF levels in suicide attempters related to psychosocial stressors: A comparative study with depression
Serum BDNF levels in suicide attempters related to psychosocial stressors: A comparative study with depression
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DOI：
10.1159/000111539
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Esen-Danaci, Aysen
中科院分区：
文献类型：
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作者：
Deveci, Artuner;Aydemir, Omer;Esen-Danaci, Aysen
尽管许多研究已经探讨了自杀的神经生物学方面，但与自杀相关的分子机制和病理生理机制仍不清楚。在这项研究中，旨在调查与重度抑郁症患者和健康受试者相比，没有严重精神疾病的自杀未遂者的血清脑源性神经营养因子（BDNF）水平是否存在差异。该研究假设自杀本身会降低血清 BDNF 水平，因为它是压力的来源。该研究在土耳其马尼萨的 Celal Bayar 大学医院进行。该研究包括 10 名自杀未遂者、24 名重度抑郁症患者和 26 名没有任何精神病诊断和任何精神病治疗的受试者。所有受试者都被要求给出书面同意。在基线时收集血样。测试前将血清BDNF保存在- 70°C，并用ELISA试剂盒（Promega; Madison, Wisc., USA）用试剂盒提供的块和样品溶液稀释后进行测定。对数据进行 Kruskal-Wallis 检验以进行非参数方差分析。自杀组（21.2 +/- 12.4 ng/ml）和重度抑郁症组（21.2 +/- 11.3 ng/ml）的平均血清 BDNF 水平显着低于对照组（31.4 +/- 8.8 ng/ml；p = 0.004）。这些结果表明 BDNF 可能在自杀行为的神经生物学中发挥重要作用。 BDNF 水平可能是自杀行为的生物标志。为了调查 BDNF 在自杀中的作用，需要进行更广泛的样本量和自杀未遂伴随的各种精神病学诊断的进一步研究。版权所有 (c) 2007 S. Karger AG，巴塞尔。
Although many studies have examined the neurobiological aspects of suicide, the molecular mechanisms and pathophysiologic mechanisms associated with suicide remain unclear. In this study, it is aimed to investigate whether there is a difference in serum brain-derived neurotrophic factor ( BDNF) levels among suicide attempters without a major psychiatric disorder, compared to major depressive disorder patients and healthy subjects. It was undertaken with the hypothesis that suicide per se lowers serum BDNF levels, since it is a source of stress. The study was carried out in Celal Bayar University Hospital, Manisa, Turkey. Ten suicide attempters, 24 patients with major depressive disorder and 26 subjects without any psychiatric diagnosis and any psychiatric treatment were included in the study. All subjects were asked to give their written consent. Blood samples were collected at the baseline. Serum BDNF was kept at - 70 degrees C before testing, and assayed with an ELISA kit ( Promega; Madison, Wisc., USA) after dilution with the block and sample solution provided with the kit. The data were subjected to the Kruskal-Wallis test for nonparametric analysis of variance. Mean serum BDNF levels were significantly lower in the suicide group (21.2 +/- 12.4 ng/ml) and the major depressive disorder group (21.2 +/- 11.3 ng/ml) than the control group (31.4 +/- 8.8 ng/ml; p = 0.004). These results suggest that BDNF may play an important role in the neurobiology of suicidal behavior. BDNF levels may be a biological marker for suicidal behavior. To investigate the role of BDNF in suicide, further studies with a wider sample size and a variety of psychiatric diagnoses accompanying suicide attempt are needed. Copyright (c) 2007 S. Karger AG, Basel.