Biological activities of Maillard reaction products (MRPs) in a sugar-amino acid model system
Biological activities of Maillard reaction products (MRPs) in a sugar-amino acid model system
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DOI：
10.1016/j.foodchem.2010.10.103
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发表时间：
2011-05-01
期刊：
影响因子：
8.8
通讯作者：
Jeong, Heon Sang
中科院分区：
文献类型：
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作者：
Hwang, In Guk;Kim, Hyun Young;Jeong, Heon Sang
对糖（果糖和葡萄糖）和20种氨基酸模型体系的美拉德反应产物（MRPs）的各种生物活性进行了评价。显色，在体外抗氧化剂，α-葡萄糖苷酶抑制，抗高血压，和抗增殖活性的水溶液中产生的MRPs加热在130 ℃下2小时进行了测量。果糖-氨基酸混合液的紫外吸收值和布朗宁强度均高于葡萄糖-氨基酸混合液。果糖-氨基酸模型MRPs清除DPPH和ABTS自由基的活性及ACE抑制活性均高于葡萄糖-氨基酸模型MRPs。果糖-和葡萄糖-酪氨酸衍生的MRPs对α-葡萄糖苷酶的抑制作用比其他MRPs表现出更高的抑制活性。糖-氨基酸模型MRPs在0.5 ~ 1.5mg/ml浓度范围内呈剂量依赖性地抑制HCT 116结肠癌细胞的生长。葡萄糖MRPs显示出比果糖MRPs稍高的抗增殖活性。特别是，糖-色氨酸和-酪氨酸MRPs比其他MRPs具有更高的生物活性。(C)2010爱思唯尔有限公司版权所有。
The various biological activities of Maillard reaction products (MRPs) from sugar (fructose and glucose) and 20 amino acid model systems were evaluated. Colour development, in vitro antioxidant, alpha-glucosidase inhibitory, antihypertensive, and antiproliferative activities of aqueous solutions of MRPs produced by heating at 130 degrees C for 2 h were measured. The fructose-amino acid mixture showed higher UV-absorbance and browning intensity than the glucose-amino acid mixture. The fructose-amino acid model MRPs showed higher DPPH and ABTS radical scavenging and ACE inhibitory activities than the glucose-amino acid model MRPs. The alpha-glucosidase inhibitory effect of MRPs derived from fructose-and glucose-tyrosine showed higher alpha-glucosidase inhibitory activity than that of other MRPs. Sugar-amino acid model MRPs inhibited the growth of HCT116 colon cancer cell in a dose-dependent manner (from 0.5 to 1.5 mg/ml). Glucose MRPs showed slightly higher antiproliferative activity than fructose MRPs. In particular, sugar-tryptophan and -tyrosine MRPs exerted higher biological activities than the other MRPs.(C) 2010 Elsevier Ltd. All rights reserved.