Seroepidemiology of gastritis in Japanese and Dutch working populations: evidence for the development of atrophic gastritis that is not related to Helicobacter pylori.
Seroepidemiology of gastritis in Japanese and Dutch working populations: evidence for the development of atrophic gastritis that is not related to Helicobacter pylori.
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日本和荷兰工作人群胃炎的血清流行病学：与幽门螺杆菌无关的萎缩性胃炎发展的证据。
作者：
R. J. Schlemper;S D van der Werf;J. P. Vandenbroucke;I. Biemond;C. Lamers
胃炎的血清学标志物，如胃炎A，胃蛋白酶原C，胃癌和幽门螺杆菌抗体，可用于探索与癌症风险对比的人群中胃粘膜状态的状态。已知胃蛋白原A：C比和增加的血清胃蛋白的降低反映了萎缩性胃炎的严重程度增加，这是胃癌的前体。在723名来自日语（n = 225）和荷兰人（n = 498）工作人群的受试者（不含胃二维的手术）中，它们的年龄组成（平均48岁），性别（男性与女性比率6：1）和分析了占用的占用类型，禁食血清样品的IgG抗体与幽门螺杆菌，胃蛋白酶原A，胃蛋白原C和胃蛋白酶的抗体。同一实验室。日本人的幽门螺杆菌感染比荷兰人的感染更为普遍（74.7％和31.3％）；正如胃蛋白酶原A非常低的那样，表明严重的粘膜萎缩（4.4％和1.6％）。在患有和没有严重粘膜萎缩的受试者中，幽门螺杆菌血清阳性率相似。在日本人和荷兰人之间，平均胃蛋白（31.8和13.4 pmol/L）和百事可乐A：C比（1.7和2.9）存在显着差异。这些跨国差异对于幽门螺杆菌阴性受试者（胃蛋白：23.7和10.3 pmol/l，胃蛋白原A：C比率：2.4和3.2）与H幽门螺杆菌阳性受试者（胃蛋白：34.6和20.1 PMOL/L，PEPSINEGEN A：： C比率：1.5和2.5）。分层为胃蛋白原A：C比的类别后，胃蛋白的跨国差异几乎消失。总之，在日语中，倍蛋白原A：C比和胃蛋白的跨国差异反映了血管中轻度和重度粘膜萎缩的患病率，而不是荷兰语中的H幽门螺杆菌阳性和负面受试者中的较高的患病率。因此，这些发现表明，在日本中，萎缩性胃炎的发展部分与幽门螺杆菌无关。
Serological markers of gastritis, like pepsinogen A, pepsinogen C, gastrin, and Helicobacter pylori antibodies, can be used to explore the state of the gastric mucosa in populations with contrasting cancer risks. A decreasing pepsinogen A:C ratio and an increasing serum gastrin are known to reflect an increasing severity of atrophic corpus gastritis, which is a precursor of gastric cancer. In 723 subjects (without gastroduodenal surgery) from Japanese (n = 225) and Dutch (n = 498) working populations, which had a similar composition of age (mean 48 years), sex (male to female ratio 6:1), and type of occupation, fasting serum samples were analysed for IgG antibodies to H pylori, pepsinogen A, pepsinogen C, and gastrin in the same laboratory. H pylori infection was significantly more prevalent in the Japanese than in the Dutch (74.7% and 31.3%); as was a very low pepsinogen A, indicative of severe mucosal atrophy (4.4% and 1.6%). Among subjects with and without severe mucosal atrophy the H pylori seropositivity rate was similar. Between the Japanese and the Dutch there were significant differences in mean gastrin (31.8 and 13.4 pmol/l) and pepsinogen A:C ratio (1.7 and 2.9). These intercountry differences were as great for H pylori negative subjects (gastrin: 23.7 and 10.3 pmol/l, pepsinogen A:C ratio: 2.4 and 3.2) as for H pylori positive subjects (gastrin: 34.6 and 20.1 pmol/l, pepsinogen A:C ratio: 1.5 and 2.5). The intercountry difference in gastrin nearly disappeared after stratification into categories of pepsinogen A:C ratio. In conclusion, the intercountry differences in pepsinogen A:C ratio and gastrin reflect a higher prevalence of mild and severe mucosal atrophy of the corpus in the Japanese than in the Dutch, both among H pylori positive and negative subjects. Thus, these findings suggest that in the Japanese the development of atrophic gastritis is in part unrelated to H pylori.
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影响因子：
158.5
作者：
PARSONNET, J;FRIEDMAN, GD;SIBLEY, RK
通讯作者：
SIBLEY, RK
意大利不同胃癌风险地区的幽门螺杆菌抗体。
DOI：
--
发表时间：
1993
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Palli,D;Decarli,A;Cipriani,F;Sitas,F;Forman,D;Amadori,D;Avellini,C;Giacosa,A;Manca,P;Russo,A
通讯作者：
Russo,A
影响因子：
7.6
作者：
Genta, RM
通讯作者：
Genta, RM
影响因子：
158.5
作者：
NOMURA, A;STEMMERMANN, GN;BLASER, MJ
通讯作者：
BLASER, MJ