Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world
Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world
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DOI：
10.1111/j.1600-0714.2007.00522.x
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发表时间：
2007-04-01
影响因子：
3.3
通讯作者：
Carpenter, William M.
中科院分区：
文献类型：
--
作者：
Buchner, Amos;Merrell, Phillip W.;Carpenter, William M.
背景：文献中没有详细记录个体口腔内小唾液腺肿瘤（IMSGT）的相对频率。本研究的目的是确定口腔病理活检服务中 IMSGT 的相对频率和分布，并将数据与世界不同地区的类似研究进行比较。 方法：来自加利福尼亚州旧金山太平洋大学太平洋口腔颌面病理学实验室的文件作为本研究的材料来源。对 20 年间所有 IMSGT 病例的档案进行了系统检索。根据 2005 年 WHO 唾液腺肿瘤分类对肿瘤进行分类。结果：在 92 860 例访问的 380 例 (0.4%) 病例中发现了 IMSGT。这是近年来报道的最大的单一来源 IMSGT 系列。在 380 个肿瘤中，224 个（59%）为良性，156 个（41%）为恶性。在良性肿瘤中，多形性腺瘤（PA）最常见（39.2%），其次是囊腺瘤（6.3%）、小管腺瘤（6.1%）、导管乳头状瘤（4.4%）、基底细胞腺瘤（1.6%）和肌上皮瘤（1.3%）。在恶性肿瘤中，粘液表皮样癌最常见（21.8%），其次是多形性低级别腺癌（7.1%）、腺样囊性癌（6.3%）、未特指的腺癌（NOS；2.1%）、腺泡细胞癌（1.6%）、透明细胞癌、NOS（1.0%）和 PA 癌(0.5%)。 结论：与来自世界不同地区的个体 IMSGT 相对频率相关的研究很难进行比较，因为许多研究已经过时、病例数少、肿瘤列表有限，并且未包括新实体。为了确定真正的相对频率，应该由唾液腺肿瘤领域经验丰富的病理学家对同一来源的大量病例进行更多研究。
BACKGROUND: The relative frequency of individual intra-oral minor salivary gland tumors (IMSGT) is not well documented in the literature. The aim of this study was to determine the relative frequency and distribution of IMSGT in an oral pathology biopsy service and to compare the data with similar studies from different parts of the world.METHODS: Files from the Pacific Oral and Maxillofacial Pathology Laboratory of the University of the Pacific, San Francisco, California served as a source of material for this study. Files were systematically searched for all cases of IMSGT during a 20-year period. Tumors were classified according to the 2005 WHO classification of salivary gland tumors.RESULTS: IMSGT were identified in 380 (0.4%) cases of 92 860 accessed. This is the largest series of IMSGT from one source reported in recent years. Of the 380 tumors, 224 (59%) were benign and 156 (41%) were malignant. Of the benign tumors, pleomorphic adenoma (PA) was the most common (39.2%), followed by cystadenoma (6.3%), canalicular adenoma (6.1%), ductal papillomas (4.4%), basal cell adenoma (1.6%), and myoepithelioma (1.3%). Of the malignant tumors, mucoepidermoid carcinoma was the most common (21.8%), followed by polymorphous low-grade adenocarcinoma (7.1%), adenoid cystic carcinoma (6.3%), adenocarcinoma, not otherwise specified (NOS; 2.1%), acinic cell carcinoma (1.6%), clear cell carcinoma, NOS (1.0%), and carcinoma ex PA (0.5%).CONCLUSIONS: Studies related to the relative frequency of individual IMSGTs from different parts of the world are difficult to compare because many studies are outdated, the number of cases is small, the list of tumors is limited, and new entities are not included. To determine the true relative frequency, more studies should be conducted, on a large number of cases from one source, by experienced pathologists in the field of salivary gland tumors.