Is there a role for pre-operative thrombocytosis in the management of colorectal cancer?
Is there a role for pre-operative thrombocytosis in the management of colorectal cancer?
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DOI：
10.1016/j.ijsu.2010.05.005
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发表时间：
2010-01-01
影响因子：
15.3
通讯作者：
Lund, Jonathan N.
中科院分区：
文献类型：
--
作者：
Nyasavajjala, Sitaramachandra Murthy;Runau, Francois;Lund, Jonathan N.
背景：高循环血小板计数与乳腺癌、肾癌和肺癌等多种实体瘤的不良预后相关。我们研究了术前高血小板计数对 I-IV 期结直肠癌患者总体生存的重要性。 患者和方法：对 2004 年至 2007 年间连续接受结直肠癌切除术的 630 名患者进行了评估，并在手术前 14 天进行了全血细胞计数。男：女7：5，中位（范围）年龄73岁（40-99岁）。血小板增多症定义为血小板计数>= 450 x 10(9)/L。评估了血小板计数、病理特征和总生存期之间的关系。结果：：Mantel-Cox 回归表明，多变量分析显示血小板计数不能预测生存期（p = 0.067）。 51/627 (8.1%) 的病例存在血小板增多症。在血小板计数= 450 x 10(9)/L（n = 51，CI：1261.6-955.0，SE 78.2）的患者中观察到平均生存率（p = 0.067）没有统计学显着差异。 Dukes分期和血小板增多之间也没有相关性。结论：在我们的研究中，无论病理分期如何，术前血小板增多并不是结直肠癌患者生存的预后指标。 (C) 2010 Surgical Associates Ltd. 由 Elsevier Ltd 出版。保留所有权利。
Background: High circulating platelet counts have been associated with poor prognosis in a variety of solid tumours such as breast, renal and lung cancer. We investigated the significance of a high pre-operative platelet count on overall survival in patients with stages I-IV colorectal cancer.Patients and methods: 630 Consecutive patients who colorectal cancer resection between 2004 and 2007 with a full blood count taken 14 days prior to the surgery were assessed. Male: female 7: 5, median (range) age 73 (40-99 years). Thrombocytosis was defined as platelet count of >= 450 x 10(9)/L. The relationship between platelet count, pathological features and overall survival was assessed.Results: : Mantel-Cox regression showed that platelet count does not predict survival on multivariate analysis (p = 0.067). Thrombocytosis was present in 51/627 (8.1%) of cases. There was no statistically significant difference in mean survival (p = 0.067) observed in patients with platelet count = 450 x 10(9)/L (n = 51, CI: 1261.6-955.0, SE 78.2). There was also no correlation between Dukes stage and thrombocytosis.Conclusion(s): In our study, pre-operative thrombocytosis is not a prognostic indicator of survival in colorectal cancer patients regardless of pathological stage. (C) 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.