Maternal traits during lactation period reduce the anxiety-related behavior in male offspring: Results from a fostering study in hatano rats
Maternal traits during lactation period reduce the anxiety-related behavior in male offspring: Results from a fostering study in hatano rats
复制标题
哺乳期的母亲特征减少雄性后代的焦虑相关行为：波多野大鼠的寄养研究结果
DOI：
10.1016/j.physbeh.2020.113209
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发表时间：
2021
期刊：
影响因子：
2.9
通讯作者：
Kawaguchi M
中科院分区：
文献类型：
--
作者：
Horii Y;Nakajima S;Akieda-Asai S;Ohta R;Kawaguchi M
选择性地饲养Sprague道利大鼠的Hatano品系以产生高（HAA）和低（LAA）主动回避变体。我们以前报道过HAA大鼠比LAA大鼠表现出更多的焦虑相关行为，但这种品系差异是否受到出生后环境因素的影响仍不清楚。在这项研究中，我们进行的HAA和LAA株之间的交叉培养，并调查了出生后的母亲的性格对每个品系的雄性后代的情绪反应的影响。采用高架十字迷宫实验评价了寄养处理对雄性子代情绪反应的影响。由HAA母鼠饲养的雄性LAA后代比由LAA母鼠饲养的后代表现出更高的焦虑相关行为。接下来，我们量化和类型的各种母亲的行为下，在哺乳期内和交叉寄养条件下使用快照抽样方法。这种方法使我们能够评估可能影响我们第一次实验中观察到的后代情绪反应的潜在母亲特征。我们发现，HAA母鼠表现出长期的休息，没有后代和后代的安排相比，LAA母鼠。这些研究结果表明，出生后的环境因素可能会改变焦虑相关的行为，在男性LAA后代和哺乳期与后代的直接接触较少，可能会诱导焦虑相关的行为，在男性后代。
The Hatano strains of the Sprague Dawley rats have been selectively bred to create high- (HAA) and low- (LAA) active avoidance variants. We previously reported that HAA rats display more anxiety-related behavior than LAA rats, but whether this strain difference is affected by postnatal environmental factors remains unclear. In this study, we performed in- and cross-fostering between the HAA and LAA strains and investigated the effect of postnatal maternal traits on the emotional responses in each strain of the male offspring. We evaluated the effect of the fostering treatment on the emotional responses of the male offspring using the elevated plus maze test. The male LAA offspring reared by HAA dam showed higher anxiety-related behavior than those reared by LAA dam. Next, we quantified and typed various maternal behavior under the in- and cross-fostering conditions during the lactation period using a snapshot sampling method. This method allowed us to evaluate potential maternal traits that may influence the emotional responses of the offspring observed in our first experiment. We found that HAA dams showed long-term resting without offspring and offspring arrangement compared with LAA dams. These findings suggest that postnatal environmental factors may alter anxiety-related behavior in the male LAA offspring and that less direct contact with their offspring during the lactation period may induce anxiety-related behavior in male offspring.