The speed of lexical activation is altered in Parkinson's disease
The speed of lexical activation is altered in Parkinson's disease
复制标题
DOI：
10.1080/13803390500507188
复制
发表时间：
2007-01-01
影响因子：
2.2
通讯作者：
Silburn, Peter A.
中科院分区：
文献类型：
--
作者：
Angwin, Anthony J.;Chenery, Helen J.;Silburn, Peter A.
帕金森病 (PD) 患者对复杂非规范句子的理解障碍与多巴胺耗竭和词汇检索延迟有关。本研究的目的是复制具有非规范句子处理困难的 PD 患者的词汇激活延迟的发现，并调查多巴胺耗竭对这些词汇访问变化的影响。在第一个实验中，20 名 PD 患者（在“服用”多巴胺能药物时进行测试）和 23 名对照者参加了列表启动实验。在此范式中，刺激以单词/非单词的连续列表的形式呈现，并且在 500 毫秒、1000 毫秒和 1500 毫秒的刺激间间隔 (ISI) 内测量语义启动效应，并使用多元方差分析对数据进行分析。结果显示，对非规范句子理解能力较差的帕金森病患者的词汇激活延迟较长，这表明帕金森病患者的词汇访问速度可能会受到影响，并且这一特征可能会导致某些句子理解困难。在第二个实验中，参与第一个实验的 7 名 PD 患者在“停用”多巴胺能药物的同时执行了相同的词汇决策任务。在 500 毫秒和 1500 毫秒的 ISI 中测量语义启动效应。组内比较揭示了帕金森病患者在“开启”药物治疗和“关闭”药物治疗时的语义启动模式不同，这为多巴胺能对信息处理和词汇激活速度的影响提供了进一步的支持。
Disturbed comprehension of complex noncanonical sentences in Parkinson's disease (PD) has been linked to dopamine depletion and delayed lexical retrieval. The aim of the present study was to replicate findings of delayed lexical activation in PD patients with noncanonical sentence processing difficulties, and investigate the influence of dopamine depletion on these changes to lexical access. In the first experiment, 20 patients with PD (tested whilst 'on' dopaminergic medication) and 23 controls participated in a list priming experiment. In this paradigm, stimuli are presented as a continuous list of words/nonwords, and semantic priming effects were measured across inter-stimulus intervals (ISIs) of 500 ms, 1000 ms and 1500 ms, with data analyzed using multivariate analyses of variance. The results revealed longer delays in lexical activation for PD patients with poor comprehension of noncanonical sentences, suggesting that the speed of lexical access may be compromised in PD, and that this feature may contribute to certain sentencecomprehension difficulties. In the second experiment, 7 patients with PD who participated in the first experiment, performed the same lexical decision task while 'off' their dopaminergic medication. Semantic priming effects were measured across ISIs of 500 ms and 1500 ms. Within group comparisons revealed a different pattern of semantic priming for the PD patients when 'on' compared to 'off' medication, providing further support for a dopaminergic influence on the speed of information processing and lexical activation.