Role of the hematopoietic stem cells in immunological memory.
Role of the hematopoietic stem cells in immunological memory.
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DOI：
10.1007/s40778-021-00204-7
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发表时间：
2022-03
影响因子：
1.4
通讯作者：
Reynaud, Damien
中科院分区：
文献类型：
--
作者：
Govindarajah, Vinothini;Reynaud, Damien
免疫记忆是免疫系统的一种重要的进化适应。以前仅限于适应性免疫系统，记忆的概念最近已扩大到先天免疫系统。本文综述了最近的研究，强调了造血干细胞（HSC）在支持免疫记忆方面的贡献。短寿命的先天免疫细胞可以建立持久的感染记忆，以改善它们对二次挑战的反应。研究表明，先天免疫系统的这些意想不到的特性是由HSC区室中的表观遗传和代谢变化维持的。HSC在对病原体的反应中持久改变，并作为先天免疫记忆的长期支持。关于HSC中诱导和维持这种免疫记忆的机制仍存在许多问题。研究这些问题将开辟新的视角，以了解环境因素如何随着时间的推移塑造HSC活动。
Immunological memory is an important evolutionary adaptation of the immune system. Previously restricted to the adaptive immune system, the concept of memory has recently been broadened to the innate immune system. This review summarizes recent studies that highlight the contribution of the hematopoietic stem cells (HSCs) in supporting immunological memory. Short-lived innate immune cells can build a long-lasting memory of infection to improve their response to secondary challenges. Studies show that these unexpected properties of the innate immune system are sustained by epigenetic and metabolic changes in the HSC compartment. HSCs are durably altered in response to pathogens and serve as long-term support for innate immune memory. Many questions remain regarding the mechanisms contributing to the induction and the maintenance of this immune memory in HSCs. Answering these questions will open new perspectives to understand how environmental factors shape the HSC activity over time.