Thyroid function before and after four-week light treatment in winter depressives and controls.
Thyroid function before and after four-week light treatment in winter depressives and controls.
复制标题
冬季抑郁症患者和对照者在四周光照治疗前后的甲状腺功能。
DOI：
10.1016/0306-4530(93)90018-g
复制
发表时间：
1993
影响因子：
3.7
通讯作者：
Marcus,JG
中科院分区：
文献类型：
--
作者：
Bauer,MS;Kurtz,J;Winokur,A;Phillips,J;Rubin,LB;Marcus,JG
根据DSM-IIIR，在具有季节性模式的复发性重性心境障碍的过程中，将当前重性抑郁发作患者的甲状腺功能与对照组在4周光照治疗前后的甲状腺功能进行比较，并与对照组在基线和未暴露于强光的情况下早起4周后的甲状腺功能进行比较。基线时，抑郁症患者的甲状腺素、游离甲状腺素指数、三碘甲状腺原氨酸、反三碘甲状腺原氨酸、促甲状腺激素、促甲状腺激素对TRH输注的反应或甲状腺自身抗体均未见一致异常。在基线时，抑郁症患者和对照组的这些参数没有差异。治疗组间无差异，尽管所有组的反向T3均显著降低。这些数据不支持甲状腺轴在冬季抑郁症状的发病机制或其对光治疗的反应中起作用的假设。
Thyroid function in patients in a current major depressive episode during the course of recurrent major mood disorder with seasonal pattern according to DSM-IIIR was compared to that of controls before and after 4 weeks' light treatment, and to that of controls at baseline and after 4 weeks' of arising early without exposure to bright light. No consistent abnormalities in thyroxine, free thyroxine index, triiodothyroine, reverse triiodothyronine, thyrotropin, thyrotropin response to TRH infusion, or thyroid autoantibodies were seen in depressives at baseline. No differences in these parameters were seen at baseline between depressives and controls. No intergroup differences were seen with treatment, although reverse T3decreased significantly during the protocol in all groups. These data do not support the hypothesis that the thyroid axis plays a role in the pathogenesis of winter depressive symptoms or their response to light treatment.