INFLUENCE OF HOSPITALIZATION ON DRUG-THERAPY IN THE ELDERLY
INFLUENCE OF HOSPITALIZATION ON DRUG-THERAPY IN THE ELDERLY
复制标题
DOI：
10.1111/j.1532-5415.1989.tb02227.x
复制
发表时间：
1989-08-01
影响因子：
6.3
通讯作者：
TAMAI, IY
中科院分区：
文献类型：
--
作者：
BEERS, MH;DANG, J;TAMAI, IY
为了确定急性住院是否会导致老年人出院后用药的变化，我们研究了197名入住某医院的老年患者入院和出院时的用药情况。我们发现，40%的入院药物是在出院时停止使用的，45%的出院药物是在住院期间新开始的。虽然从入院到出院使用的药物数量没有显著增加(4.50到4.80，p=.128)，但麻醉剂、泻药和抗生素的数量显著增加。对于那些住院的老年人服用的药物少于平均用药次数，从入院到出院，总体用药增加(2.89到3.75，P<；.0001)。这些“低服用者”使用了更多的苯二氮卓类药物、麻醉剂、泻药、抗生素和心脏药物。我们的数据表明，在住院期间，停止服药，大量开始服用新药，这些变化伴随着某些类别药物使用增加的趋势。这些变化可能会增加老年患者出现多药联用及其并发症的风险。
In order to determine whether acute hospitalization leads to changes in the medications used by the elderly after discharge, we studied the medications used at admission and discharge for 197 elderly subjects admitted to one hosptial. We found that 40% of all admission medications were discontinued by discharge and 45% of all discharge medications were newly started during the hospitalization. Although the number of drugs used did not increase significantly from admission to discharge (4.50 to 4.80, p = .128), the number of narcotics, laxatives, and antibiotics increased significantly. For those elderly subjects admitted to the hospital taking less than the average number of medications, the overall use of medication increased from admission to discharge (2.89 to 3.75, P < .0001). These ''low users" were discharged on more benzodiazepines, narcotics, laxatives, antibiotics, and cardiac medications. Our data suggest that during hospitalization admission medications are discontinued and new medications are started in large numbers and that these changes are accompanied by a tendency towards the increased use of certain categories of medications. These changes may place the elderly patient at increased risk of polypharmacy and its complications.