Emerging strategies against tumor-associated fibroblast for improved the penetration of nanoparticle into desmoplastic tumor.
Emerging strategies against tumor-associated fibroblast for improved the penetration of nanoparticle into desmoplastic tumor.
复制标题
DOI：
10.1016/j.ejpb.2021.05.007
复制
发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Chen Yunna;Huang Mengru;Wang Fengling;Wang Lei;Chen Weidong
中科院分区：
文献类型：
--
作者：
Chen Yunna;Huang Mengru;Wang Fengling;Wang Lei;Chen Weidong
由于肿瘤基质阻碍了纳米颗粒的递送，因此纳米颗粒在实体瘤，特别是促结缔组织增生性肿瘤中的治疗效果受到限制。作为肿瘤间质中最丰富的细胞，肿瘤相关成纤维细胞（TAF）产生致密的细胞外基质，这导致更高的组织流体压力，从而为纳米颗粒递送创建物理屏障。因此，研究人员专注于消除TAF以对抗促结缔组织增生性肿瘤。近年来，已经开发了一系列TAF的方法。本文首先介绍了TAFs阻碍纳米粒渗透的生物学机制。然后，总结了TAFs的不同消除方法，并重点介绍了纳米药物消除TAFs的机制。最后从促纤维增生性肿瘤的治疗角度探讨了TAFs治疗中存在的问题和未来的发展方向。
The therapeutic effect of nanoparticles is limited in solid tumors, especially desmoplastic tumors, because the tumor matrix hinders the delivery of nanoparticles. As the most abundant cells in the tumor stroma, tumor-associated fibroblasts (TAFs) produce a dense extracellular matrix, which leads to higher tissue fluid pressure, thereby creating a physical barrier for nanoparticle delivery. Therefore, researchers focused on eliminating TAFs to combat desmoplastic tumors. In recent years, a series of methods for TAFs have been developed. In this paper, we first introduced the biological mechanism of TAFs hindering the penetration of nanoparticles. Then, the different methods of eliminating TAFs were summarized, and the mechanism of nanomedicine in eliminating TAFs was highlighted. Finally, the problems and future development directions for TAFs treatment were discussed from the perspective of the treatment of desmoplastic tumors.