NUT Carcinoma Without Upfront Surgical Resection: A Case Report.
NUT Carcinoma Without Upfront Surgical Resection: A Case Report.
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DOI：
10.1097/mph.0000000000001865
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发表时间：
2021-07-01
期刊：
影响因子：
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通讯作者：
Trucco M
中科院分区：
文献类型：
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作者：
Leeman R;Pinkney K;Bradley JA;Ruiz R;DuBois SG;French C;Trucco M
NUT癌是一种罕见且高度侵袭性的癌症，诊断后1年死亡率为70%，中位生存期仅为6.5个月。虽然采用包括早期手术切除、辅助化疗和放疗在内的多模式治疗方法取得了一些成功，但目前尚无确定的治疗方案。先前的研究没有证明在没有手术切除的情况下成功治疗。我们描述了首例报道的不可切除的NUT癌患者，采用斯堪的纳维亚肉瘤第IX组方案和同步放射治疗的最终化疗成功治疗，但没有手术切除。
NUT carcinoma is a rare and highly aggressive carcinoma associated with a 70% mortality rate one year from diagnosis and a median survival of only 6.5 months. No established treatment protocol exists, though some success has been achieved using a multimodal approach including early surgical resection and adjuvant chemotherapy and radiation. Prior studies have not demonstrated successful treatment in the absence of upfront surgical resection. We describe the first reported case of a patient with unresectable NUT carcinoma treated successfully with definitive chemotherapy using the Scandinavian Sarcoma Group IX Protocol and concurrent radiation therapy, but without surgical resection.