Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline.
Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline.
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DOI：
10.1186/1750-9378-4-8
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发表时间：
2009-06-01
影响因子：
3.7
通讯作者：
Buonaguro FM
中科院分区：
文献类型：
--
作者：
Schiffman M;Clifford G;Buonaguro FM
事实上，所有宫颈癌病例都是由有限的人乳头瘤病毒 (HPV) 持续感染引起的。某些 HPV 类型，如 HPV16 和 HPV18，是明确且强效的致癌物。然而，对致癌性最弱的 HPV 类型进行分类极具挑战性。这些决定对于筛选测试和疫苗开发非常重要。本文介绍了世界卫生组织国际癌症研究机构 (IARC) 专着工作组最近采取的一种方法，以供公开讨论，以重新评估不同 HPV 类型的致癌性。
Virtually all cases of cervical cancer are caused by persistent infections with a restricted set of human papillomaviruses (HPV). Some HPV types, like HPV16 and HPV18, are clear and powerful carcinogens. However, the categorization of the most weakly carcinogenic HPV types is extremely challenging. The decisions are important for screening test and vaccine development. This article describes for open discussion an approach recently taken by a World Health Organization International Agency for Research on Cancer (IARC) Monographs Working Group to re-assess the carcinogenicity of different HPV types.