Quantitative perfusion analysis of the pancreas and duodenum in healthy dogs by use of contrast-enhanced ultrasonography
Quantitative perfusion analysis of the pancreas and duodenum in healthy dogs by use of contrast-enhanced ultrasonography
复制标题
DOI：
10.2460/ajvr.73.3.385
复制
发表时间：
2012-03-01
影响因子：
1
通讯作者：
Wallace, Johna D.
中科院分区：
文献类型：
--
作者：
Johnson-Neitman, Jennifer L.;O'Brien, Robert T.;Wallace, Johna D.
研究对比增强超声检查作为一种微创方法，用于对健康成年狗的胰腺和十二指肠灌注进行主观和定量评估，并参考邻近肝组织的灌注。和邻近的肝脏在静脉注射微泡造影剂后获得。主观评价后，从胰腺、十二指肠和肝脏中的感兴趣区域生成定量时间-强度曲线。五个造影剂的特点，代表灌注参数确定每个器官和用于统计分析：间隔到达，流入率，峰值强度（PI），峰值强度（TPI）的时间，和outflow rate.Results-Significant胰腺和十二指肠值之间的关联被发现的间隔造影剂到达，PI，TPI，和流出率。胰腺和十二指肠流入率不相关。与肝脏值相比，胰腺和十二指肠的流入和流出速率显著更快，TPI显著更短。所有3个器官的造影剂到达时间和PI无显著差异。主观评价结果与定量分析结果相一致。结论和临床相关性结果表明，超声造影可能是一种有用的，微创的方法，用于评估犬胰腺和十二指肠灌注。本文报告的健康犬的数据有助于评估胰腺和十二指肠状况及其对药物治疗的反应。(Am J Vet Res 2012;73：385-392）
Objective-To investigate contrast-enhanced ultrasonography as a minimally invasive method for the subjective and quantitative assessment of pancreatic and duodenal perfusion in healthy adult dogs, with reference to perfusion in adjacent liver tissue.Animals-8 clinically normal adult dogs.Procedures-Contrast-enhanced ultrasonograms of the right pancreatic limb, proximal portion of the descending duodenum, and adjacent liver were acquired after IV administration of a microbubble contrast medium. Following subjective evaluation, quantitative time-intensity curves were generated from regions of interest in the pancreas, duodenum, and liver. Five contrast medium characteristics representing perfusion parameters were determined for each organ and used for statistical analysis: interval to arrival, inflow rate, peak intensity (PI), time of peak intensity (TPI), and outflow rate.Results-Significant associations between pancreatic and duodenal values were found for interval to contrast medium arrival, PI, TPI, and outflow rate. Pancreatic and duodenal inflow rates were not correlated. Inflow and outflow rates were significantly faster and TPI significantly shorter for the pancreas and duodenum, compared with values for the liver. There was no significant difference among all 3 organs for interval to arrival and PI of contrast medium. Subjective evaluation findings corresponded to quantitative analysis results.Conclusions and Clinical Relevance-Results suggested that contrast-enhanced ultrasonography may be a useful, minimally invasive method for evaluating pancreatic and duodenal perfusion in dogs. The data from healthy dogs reported here could aid in the assessment of pancreatic and duodenal conditions and their response to medical treatment. (Am J Vet Res 2012;73:385-392)