Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes
Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes
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DOI：
10.2217/nnm.12.1
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发表时间：
2012-07-01
期刊：
影响因子：
5.5
通讯作者：
Saito, Naoto
中科院分区：
文献类型：
--
作者：
Ogihara, Nobuhide;Usui, Yuki;Saito, Naoto
碳纳米管（CNT）的添加显着改善了基材的机械特性。 CNT/氧化铝陶瓷复合材料有望成为可用于多种医学领域的高功能生物材料。研究了CNT/氧化铝复合材料作为生物材料的生物相容性和骨组织相容性。方法和结果：在皮下植入研究中，复合材料引起的炎症反应与单独使用氧化铝陶瓷的炎症反应一样轻微。在骨植入测试中，该复合材料表现出良好的骨组织相容性，并直接与新骨连接。对成骨细胞、软骨细胞、成纤维细胞和平滑肌细胞进行体外细胞附着测试，CNT/氧化铝复合材料表现出与氧化铝陶瓷相似的细胞附着。讨论与结论：由于碳纳米管/氧化铝复合材料具有良好的生物相容性和骨组织相容性，因此有望作为与骨接触的生物材料，例如关节置换术中的假体和骨修复装置中的应用。
The addition of carbon nanotubes (CNTs) remarkably improves the mechanical characteristics of base materials. CNT/alumina ceramic composites are expected to be highly functional biomaterials useful in a variety of medical fields. Biocompatibility and bone tissue compatibility were studied for the application of CNT/alumina composites as biomaterials. Methods & results: Inflammation reactions in response to the composite were as mild as those of alumina ceramic alone in a subcutaneous implantation study. In bone implantation testing, the composite showed good bone tissue compatibility and connected directly to new bone. An in vitro cell attachment test was performed for osteoblasts, chondrocytes, fibroblasts and smooth muscle cells, and CNT/alumina composite showed cell attachment similar to that of alumina ceramic. Discussion & conclusion: Owing to proven good biocompatibility and bone tissue compatibility, the application of CNT/alumina composites as biomaterials that contact bone, such as prostheses in arthroplasty and devices for bone repair, are expected.