Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept-source optical coherence tomography angiography
Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept-source optical coherence tomography angiography
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DOI：
10.1186/s40942-020-00209-0
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发表时间：
2020-03-19
影响因子：
2.3
通讯作者：
Waheed, Nadia K.
中科院分区：
文献类型：
--
作者：
Gendelman, Isaac;Alibhai, A. Yasin;Waheed, Nadia K.
背景本研究采用扫频光源光学相干断层扫描血管造影（SS-OCTA）技术，探讨糖尿病视网膜病变（DR）严重程度与黄斑区脉络膜毛细血管（CC）血流缺损百分比（FD %）的关系。在OCTA图像的四个不同区域中计算CC FD %：内部、中间、外部和全视野区域。采用广义估计方程（GEE）方法对糖尿病患者的眼部数据进行聚类分析，以确定年龄和疾病严重程度对FD %的影响程度。在90例患者中，33例无DR，17例轻度非增殖性DR（NPDR），8例中度NPDR，10例重度NPDR，22例增殖性DR。年龄和DR严重程度与FD %显著正相关，在两个最中心的区域研究效果更大。各地区各年龄组血流缺损百分比的增加幅度为：内0.12（p
BackgroundThe purpose of this study was to investigate the association between diabetic retinopathy (DR) severity and macular choriocapillaris (CC) flow deficit percentage (FD %) in different macular regions using swept-source optical coherence tomography angiography (SS-OCTA).MethodsDiabetic patients with SS-OCTA images were graded by severity and retrospectively assessed. CC FD % was calculated in four different regions of the OCTA image: inner, middle, outer, and full-field region. The generalized estimating equations (GEE) approach for clustered eye data was used to determine effect size and significance of age and disease severity on FD % for each region.Results160 eyes from 90 total diabetic patients met inclusion criteria. Out of 90 patients, 33 had no DR, 17 had mild nonproliferative DR (NPDR), 8 had moderate NPDR, 10 had severe NPDR and 22 had proliferative DR. Age and DR severity had a significant positive association with FD % for each region studied with a greater effect in the two centermost regions. The increase in flow deficit percentage per year of age by region was: inner 0.12 (p