Association of two variants in the interleukin-6 receptor gene and premature coronary heart disease in a Chinese Han population
Association of two variants in the interleukin-6 receptor gene and premature coronary heart disease in a Chinese Han population
复制标题
DOI：
10.1007/s11033-012-2143-5
复制
发表时间：
2013-02-01
影响因子：
2.8
通讯作者：
Ma, Genshan
中科院分区：
文献类型：
--
作者：
Chen, Zhong;Qian, Qi;Ma, Genshan
白细胞介素-6受体（IL-6 R）基因的两个新的单核苷酸多态性（SNPs; rs7529229和rs 2228145）最近与欧洲人群中的冠心病（CHD）相关。我们试图复制这一发现，并调查这两个SNP与中国汉族人群早发冠心病的严重程度和临床表型的关系。共研究了418例患者，其中包括187例冠状动脉狭窄千分之一日元50%或急性心肌梗死患者（男性< 55岁，女性< 65岁）和231例无CHD记录的对照组。进行连接酶检测反应以检测rs7529229和rs 2228145。rs7529229和rs 2228145三种基因型和等位基因频率在对照组和早发冠心病组间差异均无统计学意义（均P > 0.05），在性别分组间差异亦无统计学意义（均P > 0.05）。这两个SNP与早发冠心病的冠状动脉病变程度及临床表型均无相关性（均P > 0.05）。我们的研究结果不支持rs7529229或rs 2228145与中国汉族人群早发冠心病之间存在关联。这两个SNP在动脉粥样硬化和冠心病发生发展中的作用有待进一步研究。
Two novel single nucleotide polymorphisms (SNPs; rs7529229 and rs2228145) in the interleukin-6 receptor (IL6R) gene have recently been associated with coronary heart disease (CHD) in a European population. We sought to replicate this finding and to investigate associations of these two SNPs with the severity and clinical phenotypes of premature CHD in a Chinese Han population. A total of 418 patients were studied, including 187 cases with coronary stenosis a parts per thousand yen50 % or acute myocardial infarction (males < 55 years and females < 65 years) and 231 controls without documented CHD. A ligase detection reaction was performed to detect rs7529229 and rs2228145. There were no differences between the controls and premature CHD groups in the frequencies for the three genotypes and alleles of rs7529229 and rs2228145 (all P > 0.05), nor did they differ between the two groups when grouped by gender (all P > 0.05). There were also no associations between these two SNPs and the severity of coronary lesions or clinical phenotypes of premature CHD (all P > 0.05). Our results do not support an association between rs7529229 or rs2228145 with premature CHD in the Chinese Han population. Further studies are warranted to elucidate the role of these two SNPs in the development of atherosclerosis and CHD.