HIV Drug Resistance Early Warning Indicators in Cohorts of Individuals Starting Antiretroviral Therapy Between 2004 and 2009: World Health Organization Global Report From 50 Countries
HIV Drug Resistance Early Warning Indicators in Cohorts of Individuals Starting Antiretroviral Therapy Between 2004 and 2009: World Health Organization Global Report From 50 Countries
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DOI：
10.1093/cid/cis207
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发表时间：
2012-05-15
影响因子：
11.8
通讯作者：
Kelley, Karen F.
中科院分区：
文献类型：
--
作者：
Bennett, Diane E.;Jordan, Michael R.;Kelley, Karen F.
世界卫生组织制定了一套人类免疫缺陷病毒耐药（HIV）早期预警指标（EWI），以评估与HIV耐药相关的抗逆转录病毒治疗临床和方案因素。EWI通过提取临床记录中常规记录的数据进行监测，结果使诊所和项目管理人员能够确定应解决的问题，以最大限度地减少诊所人群中可预防的HIVDR的出现。截至2011年6月，50个国家监测了2004年至2009年期间在2107个诊所开始抗逆转录病毒治疗的EWI，涵盖131，686名患者。艾滋病预防与患者护理（适当的处方和患者监测），患者行为（依从性）和诊所/项目管理工作有关，以减少治疗中断（随访，一线ART的保留，抗逆转录病毒药物的采购和供应管理）。EWI测量这些因素，结果已用于优化患者和人群治疗结果。
The World Health Organization developed a set of human immunodeficiency virus drug resistance (HIVDR) early warning indicators (EWIs) to assess antiretroviral therapy clinic and program factors associated with HIVDR. EWIs are monitored by abstracting data routinely recorded in clinical records, and the results enable clinics and program managers to identify problems that should be addressed to minimize preventable emergence of HIVDR in clinic populations. As of June 2011, 50 countries monitored EWIs, covering 131 686 patients initiating antiretroviral treatment between 2004 and 2009 at 2107 clinics. HIVDR prevention is associated with patient care (appropriate prescribing and patient monitoring), patient behavior (adherence), and clinic/program management efforts to reduce treatment interruptions (follow up, retention on first-line ART, procurement and supply management of antiretroviral drugs). EWIs measure these factors and the results have been used to optimize patient and population treatment outcomes.