Promising therapeutic targets of endometriosis obtained from microRNA studies
Promising therapeutic targets of endometriosis obtained from microRNA studies
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DOI：
10.1007/s00795-021-00308-3
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发表时间：
2021-11
影响因子：
1.8
通讯作者：
K. Nasu;Y. Aoyagi;Ruofei Zhu;M. Okamoto;K. Kai;Y. Kawano
中科院分区：
文献类型：
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作者：
K. Nasu;Y. Aoyagi;Ruofei Zhu;M. Okamoto;K. Kai;Y. Kawano
子宫内膜异位症是一种良性肿瘤，影响6-10%的育龄妇女。迄今为止，研究表明microRNA （miRNA）的异常表达在子宫内膜异位症的发病机制中起重要作用。回顾文献，我们发现了9个过表达的mirna，并在子宫内膜异位症组织和细胞中进行了深入的研究。大多数过表达的miRNAs诱导了子宫内膜异位症的特异性特征，包括抑制细胞凋亡和蜕膜化，上调子宫内膜异位症细胞的纤维生成、侵袭、迁移、细胞增殖、细胞外基质附着、炎症和血管生成。然后，我们发现这些mirna的下游靶点分子，如早期生长反应蛋白-1、细胞外信号调节激酶、基质金属肽酶1、信号转导和转录激活因子3、环氧化酶-2、磷酸肌肽3激酶、AKT、哺乳动物雷帕霉素靶点、血管内皮生长因子- a等都是子宫内膜异位症的治疗靶点。最近的研究表明，在子宫内膜异位症中可能存在复杂的分子机制，导致mirna的发生和发展。致瘤性mirna和致瘤性mirna之间的微妙平衡可能决定了这种疾病的自然病程和对手术、药物和激素治疗的反应。对子宫内膜异位症相关mirna的进一步研究可能有助于阐明子宫内膜异位症的发病机制，并有助于开发新的治疗方法。
Endometriosis is a benign tumor that affect 6–10% women of reproductive age. To date, it is suggested that the aberrant microRNA (miRNA) expressions play important roles in the pathogenesis of endometriosis. Reviewing the literature, we found nine overexpressed miRNAs, which were thoroughly investigated in the context of endometriotic tissues and cells. Most of the overexpressed miRNAs induced endometriosis-specific characteristics including inhibition of apoptosis and decidualization, upregulation of fibrogenesis, invasion, migration, cell proliferation, attachment to extracellular matrix, inflammation, and angiogenesis in the endometriotic cells. Then, we found that the downstream target molecules of these miRNAs, such as early growth response protein-1, extracellular signal-regulated kinase, matrix metallopeptidase 1, signal transducer and activator of transcription 3, cyclooxygenase-2, phosphoinositide 3-kinase, AKT, mammalian target of rapamycin, and vascular endothelial growth factor-A are promising for the therapeutic targets of endometriosis. Recent findings suggest that complex molecular mechanisms leading to development and progression of endometriosis by miRNAs may exist in endometriosis. The meticulous balance between tumorigenic miRNAs and tumoristatic miRNAs may destine the natural course and response to the surgical, medical, and hormonal treatments of this disease. Further investigations into endometriosis-associated miRNAs may elucidate the pathogenesis of endometriosis and help to develop novel therapeutics.