Epidemiologic and environmental investigation of a recreational water outbreak caused by two genotypes of Cryptosporidium parvum in Ohio in 2000.
Epidemiologic and environmental investigation of a recreational water outbreak caused by two genotypes of Cryptosporidium parvum in Ohio in 2000.
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2000 年俄亥俄州由两种基因型小隐孢子虫引起的娱乐用水暴发的流行病学和环境调查。
DOI：
10.4269/ajtmh.2004.71.582
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Jeffrey L. Jones
中科院分区：
文献类型：
--
作者：
E. Mathieu;D. Levy;F. Veverka;M. Parrish;J. Sarisky;N. Shapiro;S. Johnston;T. Handzel;A. Hightower;L. Xiao;Yeuk;Steven York;M. Arrowood;Robin Lee;Jeffrey L. Jones
2000年8月，俄亥俄州卫生部请求协助调查一次隐孢子虫病的爆发，有700多名临床病例。进行了流行病学和环境调查。对粪便样本、池水样本和砂过滤器样本进行分析。一项基于社区的病例对照研究显示，主要危险因素是在A池游泳（优势比[OR] = 42, 95%可信区间[CI] = 12.3-144.9）。聚合酶链反应（PCR）分析结果支持了这一结论，该结果显示，在病例患者和A池过滤器样本中均存在人基因型和牛基因型细小隐孢子虫。一项基于池的病例对照研究表明，通过口接触池水（OR = 5.1, 95% CI = 2.1-12.5）或接触池水喷头（OR = 2.5, 95% CI = 1.3-4.7）的风险最高。记录了游泳池发生的粪便事故。记录显示，该游泳池符合当地卫生条例。此次暴发是由两种小孢子虫基因型（人类和牛）的共同感染引起的，强调需要采取协调一致的行动，改进娱乐用水设施的公共卫生政策，并加强关于通过游泳池传播疾病的可能性的教育。
In August 2000, the Ohio Department of Health requested assistance to investigate a cryptosporidiosis outbreak with more than 700 clinical case-patients. An epidemiologic and environmental investigation was conducted. Stool specimens, pool water, and sand filter samples were analyzed. A community-based case-control study showed that the main risk factor was swimming in pool A (odds ratio [OR] = 42, 95% confidence interval [CI] = 12.3-144.9). This was supported by results of polymerase chain reaction (PCR) analysis, which showed the presence of both the human and bovine genotypes of Cryptosporidium parvum in case-patients and samples from the filter of pool A. A pool-based case-control study indicated that the highest risk was related to exposure to pool water via the mouth (OR = 5.1, 95% CI = 2.1-12.5) or to pool sprinklers (OR = 2.5, 95% CI = 1.3-4.7). Fecal accidents at the pool were documented. Records indicated that the pool met local health regulations. The outbreak, caused by co-infection with two C. parvum genotypes (human and bovine), underscores the need for concerted action to improve public health policies for recreational water facilities and enhanced education regarding the potential for disease transmission through pools.
人类实验性感染后抗体对 27、17 和 15 kDa 隐孢子虫抗原的反应。
DOI：
10.1086/515377
发表时间：
1998
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Moss,DM;Chappell,CL;Okhuysen,PC;DuPont,HL;Arrowood,MJ;Hightower,AW;Lammie,PJ
通讯作者：
Lammie,PJ