Targeting treatable traits in severe asthma: a randomised controlled trial
Targeting treatable traits in severe asthma: a randomised controlled trial
复制标题
DOI：
10.1183/13993003.01509-2019
复制
发表时间：
2020-03-01
影响因子：
24.3
通讯作者：
Gibson, Peter G.
中科院分区：
文献类型：
--
作者：
McDonald, Vanessa M.;Clark, Vanessa L.;Gibson, Peter G.
基本原理：可治疗的特征已被提出作为一种新的范式气道疾病management.Objectives：在严重哮喘人群中的可治疗的特征，并确定针对这些可治疗的特征在严重asthma.Methods：参与者（n=140）与严重asthma招募到一个横断面研究，并进行了多维评估，以确定可治疗的特征。符合条件的重度哮喘受试者（n=55）参加了一项为期16周的平行组随机对照试验，以确定与重度哮喘诊所的常规治疗相比，针对预定义可治疗特征的管理的可行性和有效性。患者报告的健康相关的生活质量的结果是试验的主要endpoint.Main结果：严重哮喘的参与者平均+/- SD为10.44 +/- 3.03特征，包括3.01 +/- 1.54肺和4.85 +/- 1.86肺外特征和2.58 +/- 1.31行为/风险因素。针对这些特征的个体化治疗是可行的，并显著改善了健康相关的生活质量（0.86个单位，p
Rationale: Treatable traits have been proposed as a new paradigm for airway disease management.Objectives: To characterise treatable traits in a severe asthma population and to determine the efficacy of targeting treatments to these treatable traits in severe asthma.Methods: Participants (n=140) with severe asthma were recruited to a cross-sectional study and underwent a multidimensional assessment to characterise treatable traits. Eligible participants with severe asthma (n=55) participated in a 16-week parallel-group randomised controlled trial to determine the feasibility and efficacy of management targeted to predefined treatable traits, compared to usual care in a severe asthma clinic. The patient-reported outcome of health-related quality of life was the trial's primary end-point.Main results: Participants with severe asthma had a mean +/- SD of 10.44 +/- 3.03 traits per person, comprising 3.01 +/- 1.54 pulmonary and 4.85 +/- 1.86 extrapulmonary traits and 2.58 +/- 1.31 behavioural/risk factors. Individualised treatment that targeted the traits was feasible and led to significantly improved health-related quality of life (0.86 units, p