Cavity macrophages stop anti-tumor T cells.
Cavity macrophages stop anti-tumor T cells.
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腔内巨噬细胞会阻止抗肿瘤 T 细胞。
DOI：
10.1016/j.ccell.2021.06.007
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发表时间：
2021
期刊：
影响因子：
50.3
通讯作者：
Ruffell,Brian
中科院分区：
文献类型：
--
作者：
Rodriguez,PauloC;Ruffell,Brian
巨噬细胞如何调节免疫治疗的反应仍不清楚。在本期《癌细胞》杂志上，Chow等人。展示TIM-4+腔巨噬细胞促进肿瘤的作用，从而影响转移性恶性肿瘤对免疫治疗的反应。具体地说，TIM-4+巨噬细胞与表达磷脂酰丝氨酸的细胞毒性T淋巴细胞接触，即使在PD-1阻断期间也抑制它们的活性。
Precisely how macrophages regulate response to immunotherapy remains unclear. In this issue ofCancer Cell, Chow et al. demonstrate a tumor-promoting role of TIM-4+cavity macrophages which affects the response of metastatic malignancies to immunotherapy. Specifically, TIM-4+macrophages engage with phosphatidylserine-expressing cytotoxic T lymphocytes, inhibiting their activity even during PD-1 blockade.